| 100% | AMBERGRIS | 9 | Secretion that's the subject of a chapter in Moby-Dick |
| 59% | SPAM | 4 | Food that's the subject of a museum in Austin, Minn. |
| 49% | LYNDON | 6 | Johnson that's the subject of a museum at the University of Texas |
| 48% | BLT | 3 | Sandwich that's the subject of a "Manifesto" by J. Kenji López-Alt, for short |
| 48% | ENRON | 5 | Company that's the subject of "The Smartest Guys in the Room" |
| 48% | ASPEN | 5 | Tree that's the name of a city in Colorado |
| 48% | ENO | 3 | Brian who's the subject of a documentary that's different every time it's screened |
| 47% | NOUN | 4 | Part of speech that's the subject of a sentence, typically |
| 47% | IRS | 3 | Agency that's the subject of the book "Confessions of a Tax Collector": Abbr. |
| 47% | VERSE | 5 | Part of a chapter in the Bible |
| 46% | BEER | 4 | Drink that's the subject of several rules in the Code of Hammurabi |
| 46% | OCCUPANCY | 9 | The percentage of a hotel's rooms that are in use |
| 45% | ISLEROYALE | 10 | Lake Superior locale that's the subject of a more than 60 year study of a unique moose-wolf relationship |
| 45% | PAW | 3 | Part of a dog that's in the Iams logo |
| 45% | OLDMACDONALD | 12 | Subject of a children's song associated with the vowels in the answer to each starred clue |
| 45% | ATHENA | 6 | Subject of a massive statue in the ancient Parthenon |
| 44% | ARBOR | 5 | Subject of a celebration on the last Friday in April |
| 44% | GTO | 3 | Car that was the subject of a 1964 top 10 hit |
| 44% | OBAMA | 5 | Subject of a Kehinde Wiley portrait in the National Portrait Gallery |
| 44% | CIA | 3 | Grp. that was the subject of a recent WikiLeaks release |
| 44% | AESOP | 5 | Classical subject of a Velázquez painting in the Prado |
| 43% | LUTE | 4 | Subject of a lesson for Katharina in "The Taming of the Shrew" |
| 43% | LUTE | 4 | Subject of a lesson for Katherine in “The Taming of the Shrew” |
| 43% | EMI | 3 | Co. that was the subject of a Sex Pistols diss track |
| 43% | XIII | 4 | Apollo mission that was the subject of a 1995 film |
| 43% | EXT | 3 | Kind of shot that's the opposite of a 47-Across in a screenplay |
| 43% | INT | 3 | Kind of shot that's the opposite of a 38-Down in a screenplay |
| 43% | OWL | 3 | Bird that's a harbinger of death in "Killers of the Flower Moon" |
| 43% | NCAA | 4 | Org. that was the subject of a 2021 Supreme Court antitrust ruling |
| 43% | AOL | 3 | Tech company that was the subject of a 1997 Time cover |