| 100% | SYR | 3 | Setting for 400+ miles of the Euphrates: Abbr. |
| 47% | EDT | 3 | Setting for home games of the O's |
| 47% | CAVERN | 6 | Setting for a Pirates of the Caribbean ride |
| 47% | PADUA | 5 | Setting for "The Taming of the Shrew" |
| 47% | MST | 3 | Setting for the Rockies, sometimes: abbr. |
| 47% | SEA | 3 | Setting for much of the "Odyssey" |
| 47% | OESTE | 5 | Setting for the setting of el sol |
| 47% | TARA | 4 | Setting for the biggest movie of 1939 |
| 47% | INDIA | 5 | Setting for much of the movie "Lion" |
| 47% | TOMB | 4 | Setting for the very end of "Aida" |
| 46% | TIBET | 5 | Setting for the novel "The Magician of Lhasa" |
| 46% | PAST | 4 | Setting for much of "Back to the Future" |
| 46% | TARA | 4 | Setting for the highest-grossing movie of 1939 |
| 46% | CAFE | 4 | Setting for many Manet paintings of the bourgeoisie |
| 46% | HOMETOWN | 8 | Setting for the early chapters of a biography |
| 46% | FRI | 3 | End of the work week, for most: Abbr. |
| 45% | UTAH | 4 | Setting for the beginning of "The Book of Mormon" |
| 45% | ABBEY | 5 | Setting for the start of "The Sound of Music" |
| 45% | CAPEANN | 7 | Setting for Longfellow's "The Wreck of the Hesperus" |
| 45% | DENVER | 6 | Setting for part of Kerouac's "On the Road" |
| 45% | ALASKANINTERIOR | 15 | Setting for much of the 33-Across/16-Down |
| 45% | TORTUGA | 7 | Island setting for "Pirates of the Caribbean" |
| 45% | PST | 3 | Ore. setting for part of the year |
| 45% | SGT | 3 | Preston of the Yukon, for one: Abbr. |
| 45% | LBS | 3 | About 1,400 of them is the record for a human: Abbr. |
| 45% | SWEDEN | 6 | Setting for much of “The Girl with the Dragon Tattoo” |
| 45% | SEWER | 5 | Setting for much of the 2006 animated film "Flushed Away" |
| 45% | ASIA | 4 | Setting for the FIFA World Cups of 2002 and 2022 |
| 45% | FOLSOM | 6 | ___ Prison, setting for the 1979 film "Jericho Mile" |
| 45% | PALAU | 5 | Micronesian setting for the 10th season of "Survivor" |