| 100% | BEVERLYDANGELO | 14 | She played Ellen Griswold in "National Lampoon's Vacation": 2 wds. |
| 65% | CHEVYCHASE | 10 | He played Clark Griswold in the 1983 comedy "National Lampoon's Vacation": 2 wds. |
| 58% | CHEVYCHASE | 10 | "National Lampoon's Vacation" star who played golfer Ty Webb in "Caddyshack": 2 wds. |
| 57% | RANDYQUAID | 10 | He played Cousin Eddie Johnson in "National Lampoon's Vacation": 2 wds. |
| 50% | CHEVYCHASE | 10 | "National Lampoon's Vacation" star who starred in "Seems Like Old Times": 2 wds. |
| 45% | LAURALINNEY | 11 | She played First Lady Abigail Adams in HBO's 2008 miniseries "John Adams": 2 wds. |
| 45% | JANEALEXANDER | 13 | She played First Lady Eleanor Roosevelt in ABC's 1976 movie "Eleanor and Franklin": 2 wds. |
| 44% | JUDYGARLAND | 11 | She played Dorothy in 31-Across: 2 wds. |
| 44% | MOLLYRINGWALD | 13 | She played "the princess" Claire in "The Breakfast Club": 2 wds. |
| 44% | SUSANSARANDON | 13 | She played Sister Helen Prejean in "Dead Man Walking": 2 wds. |
| 44% | DREWBARRYMORE | 13 | She played Gertie in "E.T. the Extra-Terrestrial": 2 wds. |
| 44% | MERYLSTREEP | 11 | She played Sister Aloysius Beauvier in "Doubt": 2 wds. |
| 44% | JENNIFERGREY | 12 | She played "Baby" in 17-Across: 2 wds. |
| 43% | WINONARYDER | 11 | She played goth girl Lydia Deetz in "Beetlejuice": 2 wds. |
| 43% | JODIEFOSTER | 11 | She plays Secretary Delacourt in "Elysium": 2 wds. |
| 43% | LINDAHAMILTON | 13 | She played Sarah Connor in "Terminator 2: Judgment Day": 2 wds. |
| 43% | MAGGIESMITH | 11 | She played Mother Superior in "Sister Act": 2 wds. |
| 43% | NAOMIEHARRIS | 12 | She plays Eve Moneypenny in 38-Across: 2 wds. |
| 42% | ALLYSHEEDY | 10 | She played "the basket case" Allison in "The Breakfast Club": 2 wds. |
| 42% | KATHLEENTURNER | 14 | She played romance novelist Joan Wilder in "Romancing the Stone": 2 wds. |
| 42% | CATEBLANCHETT | 13 | She plays Galadriel in "The Hobbit: The Desolation of Smaug": 2 wds. |
| 42% | OPRAHWINFREY | 12 | She plays civil rights activist Annie Lee Cooper in "Selma": 2 wds. |
| 41% | KATIEHOLMES | 11 | She played First Lady Jacqueline Kennedy in Reelz' 2011 miniseries "The Kennedys": 2 wds. |
| 41% | JULIEANDREWS | 12 | She played Anne Hathaway's grandmother in the "Princess Diaries" films: 2 wds. |
| 41% | KELLYMCGILLIS | 13 | She played Charlie in "Top Gun": 2 wds. |
| 41% | JANEFONDA | 9 | She plays Hillary Altman in "This Is Where I Leave You": 2 wds. |
| 40% | VALERIEHARPER | 13 | She played Rhoda Morgenstern in a "Mary Tyler Moore Show" spin-off: 2 wds. |
| 40% | ZOESALDANA | 10 | She played Gamora in "Guardians of the Galaxy": 2 wds. |
| 40% | RENERUSSO | 9 | She played Frigga in "Thor: The Dark World": 2 wds. |
| 40% | WANDASYKES | 10 | She played Louise Jefferson in the 2019 live re-creation of "The Jeffersons": 2 wds. |