| 100% | GRACESLICK | 10 | She replaced Signe Anderson as lead singer of Jefferson Airplane: 2 wds. |
| 51% | DAVIDGILMOUR | 12 | He replaced Syd Barrett as lead singer of Pink Floyd: 2 wds. |
| 46% | SAMMYHAGAR | 10 | He replaced David Lee Roth as lead singer of Van Halen: 2 wds. |
| 42% | PETERGABRIEL | 12 | Lead singer of Genesis who was replaced by Phil Collins in 1975: 2 wds. |
| 42% | ZOOEYDESCHANEL | 14 | "New Girl" actress and lead singer of the band She & Him: 2 wds. |
| 41% | OZZYOSBOURNE | 12 | Lead singer of Black Sabbath who was replaced by Ronnie James Dio in 1979: 2 wds. |
| 41% | DIANAROSS | 9 | She was once lead singer of the Supremes: 2 wds. |
| 38% | PATRICKSTUMP | 12 | Lead singer of 17-Across: 2 wds. |
| 38% | NICKLACHEY | 10 | 98 Degrees lead singer who won the fifth season of "The Masked Singer" as the Piglet: 2 wds. |
| 37% | FRANKZAPPA | 10 | Lead singer of the Mothers of Invention: 2 wds. |
| 37% | SHIRLEYMANSON | 13 | Female lead singer of Garbage: 2 wds. |
| 37% | CHRISSIEHYNDE | 13 | Female lead singer of the Pretenders: 2 wds. |
| 36% | NATALIEMAINES | 13 | Female lead singer of the Dixie Chicks: 2 wds. |
| 36% | GEORGEMICHAEL | 13 | Lead singer of Wham! who had the 1988 solo hit "Faith": 2 wds. |
| 36% | MICKJAGGER | 10 | Lead singer of the Rolling Stones who was knighted in 2003: 2 wds. |
| 35% | DAVIDLEEROTH | 12 | Lead singer of Van Halen who was replaced by Sammy Hagar in 1985: 3 wds. |
| 35% | JERRYGARCIA | 11 | Lead singer of the Grateful Dead who served in the US Army in 1960: 2 wds. |
| 34% | DAVEGROHL | 9 | Drummer who's the lead singer of Foo Fighters: 2 wds. |
| 34% | DEBBIEHARRY | 11 | Lead singer of Blondie who received the first Billboard Women in Music Icon Award, in 2008: 2 wds. |
| 34% | JACKBLACK | 9 | "Jumanji: Welcome to the Jungle" actor and lead singer of the band Tenacious D: 2 wds. |
| 33% | DIANAROSS | 9 | American singer who was the lead singer of "The Supremes" and is known for her solo songs like "Upside Down": 2 wds. |
| 33% | CHRISCORNELL | 12 | Late lead singer of 29-Across and Audioslave (2 wds.) |
| 32% | RICOCASEK | 9 | Lead singer of The Cars who passed away September 15, 2019 (2 wds.) |
| 32% | HAROLDMELVIN | 12 | Co-founder and lead singer of 30-Across (2 wds.) |
| 32% | WHITERABBIT | 11 | 1967 hit for Jefferson Airplane with a sign of the Chinese zodiac in its title: 2 wds. |
| 31% | MICKJAGGER | 10 | Lead singer of the Rolling Stones who turned 77 on July 26, 2020 (2 wds.) |
| 31% | HILLARYSCOTT | 12 | Lead singer of Lady A who provides vocals for 36-Across's "Be a Light" (2 wds.) |
| 30% | MICKJAGGER | 10 | "The Rolling Stones" lead singer who cameoed in "The Simpsons" episode, "How I Spent My Strummer Vacation" as himself: 2 wds. |
| 30% | DARIUSRUCKER | 12 | Hootie and the Blowfish lead singer who's getting a Recording star on the Hollywood Walk of Fame in 2024: 2 wds. |
| 29% | CHRISSIEHYNDE | 13 | Lead singer for 15-Across: 2 wds. |