| 100% | JOHNWATSON | 10 | Sherlock Holmes's sidekick: 2 wds. |
| 67% | DRWATSON | 8 | Sherlock Holmes' assistant: 2 wds. |
| 58% | WILLFERRELL | 11 | "Anchorman" actor who plays Sherlock Holmes in the upcoming movie "Holmes & Watson": 2 wds. |
| 54% | WATSON | 6 | Sherlock Holmes' sidekick |
| 53% | WATSON | 6 | Dr. John H. ___, war veteran who is Sherlock Holmes's friend and sidekick |
| 53% | LEEMILLER | 9 | Jonny ___ - whose birthday it is today - the actor who portrays Sherlock Holmes on the hit TV series "Elementary": 2 wds. |
| 52% | JUDELAW | 7 | Costar of Robert Downey, Jr. in the Sherlock Holmes films: 2 wds. |
| 47% | JOHNWATSON | 10 | Sherlock Holmes's chronicler |
| 47% | MYCROFT | 7 | Sherlock Holmes's brother |
| 47% | WATSON | 6 | Sherlock Holmes's colleague |
| 46% | ADLER | 5 | Sherlock Holmes's love Irene ___ |
| 46% | WATSON | 6 | Sherlock Holmes's friend John |
| 46% | WATSON | 6 | Sherlock Holmes's best friend |
| 45% | ENOLA | 5 | Sherlock Holmes's sister, on Netflix |
| 45% | IRENEADLER | 10 | Fictional opera singer/actress who outsmarts Sherlock Holmes in the Arthur Conan Doyle story "A Scandal in Bohemia" (2 wds.) |
| 44% | AQUILINE | 8 | Like Sherlock Holmes's nose |
| 44% | AFOOT | 5 | Like Sherlock Holmes's "game" |
| 43% | DEERSTALKER | 11 | Part of Sherlock Holmes's attire |
| 43% | DOCTOR | 6 | With 41-Across, Sherlock Holmes's confidant |
| 42% | JONNYLEEMILLER | 14 | Actor who played Sherlock Holmes on "Elementary": 3 wds. |
| 42% | SIDESHOWBOB | 11 | Krusty the Clown's sidekick on 43-Across: 2 wds. |
| 41% | JUDELAW | 7 | Actor who plays John Watson in the 2009 film "Sherlock Holmes" (2 wds.) |
| 41% | OKLAHOMACITY | 12 | The NBA's Thunder: 2 wds. |
| 41% | LETSON | 6 | Reveals one's feelings: 2 wds. |
| 41% | ATA | 3 | Move ___ snail's pace: 2 wds. |
| 41% | IMY | 3 | "Am ___ brother's keeper?": 2 wds. |
| 41% | ISEE | 4 | "Now it's clear": 2 wds. |
| 41% | IMIN | 4 | Poker bettor's phrase: 2 wds. |
| 41% | NOTCOOL | 7 | "Dude, that's harsh": 2 wds. |
| 41% | ATA | 3 | Go ___ snail's pace: 2 wds. |