| 100% | DOMEE | 5 | Shi who was the first woman to have the sole director’s credit on a Pixar feature, for “Turning Red” |
| 43% | ELAYNE | 6 | Boosler who was the first woman to have an hour-long comedy special on cable TV |
| 42% | DOROTHYARZNER | 13 | “The Bride Wore Red” director who was the first woman to join the Directors Guild of America |
| 42% | EDITH | 5 | Wharton who was the first woman to win a Pulitzer Prize for fiction |
| 42% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 41% | ANNE | 4 | Sci-fi writer McCaffrey, who was the first woman to win a Hugo for fiction |
| 41% | ALICIAKEYS | 10 | "Girl on Fire" singer/pianist who was the first woman to have an "MTV Unplugged" album debut at #1 (2 wds.) |
| 41% | RETTON | 6 | Gymnast Mary Lou who was the first woman to appear on the front of a Wheaties box |
| 40% | AVA | 3 | Director DuVernay who was the first African-American woman nominated for a Best Picture Oscar |
| 40% | AVA | 3 | Director DuVernay who was the first African American woman nominated for a Best Picture Oscar |
| 40% | JOHNMADDEN | 10 | Football player turned broadcaster who was the first one to have worked for all of the "Big Four" TV networks: 2 wds. |
| 39% | CAROLEKING | 10 | "You've Got a Friend" singer/pianist who was the first woman to win a Grammy for Song of the Year (2 wds.) |
| 38% | AVADUVERNAY | 11 | "Selma" director who was the first African-American woman nominated for a Best Picture Oscar (2 wds.) |
| 38% | EDITH | 5 | Wharton who was the first woman to win the Pulitzer Prize for Literature |
| 38% | RONALDREAGAN | 12 | U.S. president who was the first born in Illinois, the first to have been divorced, and the first to nominate a woman to the Supreme Court (2 wds.) |
| 38% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 37% | VINCE | 5 | Environmental journalist Gaia ___ who was the first woman to win the Royal Society Winton Prize for Science Books |
| 37% | ITO | 3 | Olympic skater who was the first woman to land a triple axel in competition |
| 37% | ITO | 3 | Skater Midori who was the first woman to land a triple axel in competition |
| 37% | REBA | 4 | McEntire who is the first woman to portray Colonel Sanders in a KFC ad |
| 37% | LORNASIMPSON | 12 | "Projects 23" photographer who was the first African-American woman to have a solo exhibition at the Museum of Modern Art (2 wds.) |
| 36% | BLACKWELL | 9 | Elizabeth ___, British physician who was the first woman to earn a medical degree in the US |
| 36% | JOAN | 4 | ___ Rivers, comedian and actress who was the first woman to host a late-night network TV talk show |
| 36% | OMAR | 4 | Ilhan who was the first person to wear a hijab on the House floor |
| 35% | GRETAGERWIG | 11 | "Lady Bird" director who was the fifth woman nominated for a Best Director Oscar (2 wds.) |
| 35% | SOFIACOPPOLA | 12 | "Lost in Translation" director who was the third woman nominated for a Best Director Oscar (2 wds.) |
| 35% | RENO | 4 | Janet who was the first woman to serve as U.S. attorney general |
| 35% | HELEN | 5 | I was the first deaf-blind person to earn a B.A. degree and I campaigned for women's rights |
| 35% | ANGELA | 6 | Bassett who was the first person to be nominated for an Oscar for acting in a Marvel movie |
| 35% | TYRA | 4 | Banks who was the first African-American woman featured on the cover of "GQ" |