| 100% | APU | 3 | Shopkeeper who first appears in the "Simpsons" episode "The Telltale Head" |
| 61% | ABE | 3 | Animated character who first appeared in the Simpsons short "Grandpa and the Kids" |
| 55% | ABE | 3 | "Simpsons" character who first appeared in the cartoon "Grampa and the Kids" |
| 52% | NANCYDREW | 9 | Character who first appeared in "The Secret of the Old Clock" |
| 50% | BILLY | 5 | Speedy British comic character who first appeared in The Beano in 1964 |
| 49% | DAFFY | 5 | Cartoon duck who first appeared in the 1937 short "Porky's Duck Hunt" |
| 49% | XENA | 4 | Character who first appeared in "Hercules: The Legendary Journeys" |
| 49% | WORF | 4 | Character who has appeared in the most episodes of the various "Star Trek" series |
| 49% | ELMO | 4 | Red Muppet who first appeared in the "Sesame Street" song "We Are All Monsters" |
| 49% | GEORGESMILEY | 12 | Fictional spy who first appeared in "Call for the Dead" |
| 49% | ODIE | 4 | Dog who first appeared on the comic pages in 1978 |
| 48% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in The House Without a Key |
| 48% | FLASH | 5 | The —, comic book character, alter ego Jay Garrick, who first appeared in 1940 |
| 47% | DOCSAVAGE | 9 | Fictional character created by Lester Dent who first appeared in 1933 pulp novel The Man of Bronze |
| 47% | KRYPTO | 6 | ___ the Superdog, Superman's pet dog from DC Comics who first appeared in 1955 |
| 47% | ACE | 3 | ___ the Bat-Hound, Batman's pet dog from DC Comics who first appeared in 1955 |
| 47% | THEEXCHANGE | 11 | 2023 novel by 41-Across that features lawyer Mitch McDeere, who first appeared in the 1991 novel "The Firm" (2 wds.) |
| 46% | PADME | 5 | Queen who first appears in “The Phantom Menace” |
| 46% | YODA | 4 | Alien who first appears in "The Empire Strikes Back" |
| 46% | HUCKLEBERRY | 11 | ___ Finn, a fictional character who first appeared in 51a and is a friend of the protagonist |
| 45% | OONA | 4 | Actress Chaplin who appeared in the first season of "Game of Thrones" |
| 45% | CAMPION | 7 | Albert —, detective creation of Margery Allingham who first appeared in 1929 novel The Crime At Black Dudley |
| 45% | SEXTONBLAKE | 11 | Fictional detective who first appeared in 1893 story The Missing Millionaire by Hal Meredeth aka Harry Blyth |
| 45% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in 1925 novel The House Without a Key |
| 45% | YODA | 4 | "Star Wars" character who first appears in "The Empire Strikes Back" |
| 45% | CHAN | 4 | Fictional character who first appeared in "The House Without a Key" |
| 45% | NANCYDREW | 9 | Fictional girl detective who first appeared in 1930 novel The Secret of the Old Clock by Carolyn Keene |
| 45% | PERRYMASON | 10 | Lawyer creation of Erle Stanley Gardner who first appeared in 1933 novel The Case of the Velvet Claws |