| 100% | VAX | 3 | Shot that produces an immune response to a virus, slangily |
| 54% | ANTIBODY | 8 | A protein that produces an immune response |
| 38% | OUCH | 4 | Response to a shot, maybe |
| 37% | HARHAR | 6 | Response to a cheap shot, say |
| 37% | REFLEX | 6 | An involuntary response to a stimulus |
| 36% | ALLERGY | 7 | An immune reaction to a sensitivity or irritant |
| 36% | LOL | 3 | Response to a joke in an I.M. |
| 36% | ALLERGY | 7 | Bodily response to a food that irritates |
| 35% | BOO | 3 | Audience response to a joke that goes too far |
| 34% | ETTU | 4 | Response to an attack by a group of senators |
| 34% | HITUP | 5 | Shoot a text to, slangily |
| 33% | LOB | 3 | Tennis shot that takes a while to land |
| 33% | TLDR | 4 | Response to an email that goes on and on, say: Abbr. |
| 33% | EVE | 3 | Response to "Madam, I'm Adam" that is itself a palindrome |
| 33% | LOB | 3 | Tennis shot that takes a long time to land |
| 32% | LOB | 3 | Tennis shot that takes a while to hit the court |
| 32% | IDO | 3 | Response that has a nice ring to it? |
| 32% | INTHISECONOMY | 13 | Jokey question in response to a statement that may have nothing to do with money |
| 32% | LOB | 3 | Tennis shot that takes a long time to hit the court |
| 32% | FLU | 3 | ___ shot (vaccine that helps prevent a winter virus) |
| 32% | ALOE | 4 | African plant that produces a gel said to help cool sunburn pain |
| 31% | LBOMB | 5 | Word that takes a relationship to the next level, slangily |
| 31% | METEORITE | 9 | A chunk of an asteroid that's fallen to earth |
| 31% | YES | 3 | Wry response to a this-or-that question |
| 31% | LIMO | 4 | Car that takes a celebrity to an event |
| 31% | AIMS | 4 | Prepares to shoot an arrow at a target |
| 31% | BUTISITARTIE | 12 | Response to "That's a good clarinetist"? |
| 31% | MAGNETO | 7 | Small electric generator such as that producing a spark in an internal combustion engine |
| 30% | YIPS | 4 | Nervous condition that make you miss a shot, to golfers |
| 30% | EWE | 3 | Animal that mates with a buck to produce a geep |