| 100% | PSY | 3 | Singer in the first YouTube video to surpass 1 billion views |
| 55% | BABYSHARK | 9 | Subject of the first YouTube video to reach 10 billion views (2022) |
| 42% | ADELE | 5 | She holds the Guinness record for "fastest time for a video to reach 1 billion views on YouTube" |
| 41% | PSY | 3 | First music artist to have a video with a billion YouTube views |
| 41% | STYLE | 5 | "Gangnam ___" (first YouTube video to pass a billion views) |
| 40% | KATYPERRY | 9 | "Roar" singer with more than 42 million YouTube subscribers who was the first artist to have multiple music videos reach one billion views on YouTube (2 wds.) |
| 38% | DESPACITO | 9 | 2017 chart-topping hit whose YouTube video was the first to reach 3 billion views |
| 38% | PSY | 3 | South Korean singer whose hit single "Gangnam Style" went viral becoming the first video on YouTube to exceed one billion views |
| 35% | GANGNAM | 7 | "___ Style," first video with a billion YouTube views |
| 35% | BOOMBAYAH | 9 | 2020 51-Across song that was the first K-pop debut music video to pass one billion views on YouTube |
| 34% | MDA | 3 | Org. whose telethon was the first to be viewed globally via the internet in 1998 |
| 34% | RODSTEWART | 10 | Singer who performed his song "Infatuation" to open the first MTV Video Music Awards, in 1984: 2 wds. |
| 33% | BABY | 4 | "___ Shark" (song featured in the most-viewed YouTube video ever) |
| 32% | AINT | 4 | Contraction heard in the first ''Jazz Singer'' |
| 32% | IGGYAZALEA | 10 | "Fancy" singer featured on "Problem" who in 2014 became the second ever to be simultaneously #1 and #2 with her first two hits: 2 wds. |
| 32% | TORIKELLY | 9 | "Nobody Love" singer who first started posting videos on YouTube at the age of 14: 2 wds. |
| 31% | DESPACITO | 9 | Reggaeton song by singer Luis Fonsi featuring Daddy Yankee which is the most viewed music video on YouTube |
| 31% | DESPACITO | 9 | Song whose music video was surpassed by Pinkfong’s “Baby Shark Dance” as the most-viewed video on YouTube, in 2020 |
| 31% | HAND | 4 | "I Want to Hold Your ___," 1963 song by The Beatles which was their first number 1 hit in America |
| 31% | HEAD | 4 | The first blank in this phrase: From ___ to ___ |
| 30% | RHODA | 5 | First TV show to debut at #1 in the Nielsen ratings |
| 30% | SNEEZED | 7 | What Fred Ott did in the first movie to be copyrighted |
| 30% | TITANIC | 7 | The first film to reach the billion-dollar mark |
| 30% | MOTOROLA | 8 | The first company to sell a cellphone, in 1973 |
| 30% | BILLIEEILISH | 12 | First artist born in the two-thousands to reach No. 1 on the Billboard Hot 100 (August, 2019) |
| 30% | AHA | 3 | First Norwegian band to have a #1 hit in the US: Hyph. |
| 30% | VIRAL | 5 | Like a YouTube video with a billion views |
| 30% | LEONOV | 6 | Russian cosmonaut, the first to walk in space |
| 30% | OSLO | 4 | City hidden in the answer to 1-Down |
| 30% | JACKIESTILES | 12 | 2016 Women's Basketball Hall of Fame inductee who was the first Division I player to score over 1,000 points in a season: 2 wds. |