| 100% | ELLEN | 5 | Sitcom set in a bookstore |
| 75% | SANFORDANDSON | 13 | Sitcom set in a junkyard |
| 74% | APBIO | 5 | Sitcom set in a high school |
| 72% | APBIO | 5 | Sitcom set in a H.S. science class |
| 71% | TAXI | 4 | Tony Danza sitcom set in a garage |
| 71% | TAXI | 4 | Danny DeVito sitcom set in a garage |
| 71% | TAXI | 4 | Old sitcom set in a cab compaany |
| 71% | NIGHT | 5 | "___ Court" (rebooted sitcom set in a courtroom) |
| 71% | GHOSTS | 6 | CBS sitcom set in a haunted mansion |
| 71% | ABBOTTELEMENTARY | 16 | *Quinta Brunson sitcom set in a school |
| 70% | BOBS | 4 | "___ Burgers" (animated sitcom set in a family diner) |
| 70% | CHEERS | 6 | US television sitcom set in a Boston bar |
| 70% | TAXI | 4 | Classic Emmy-winning sitcom set in a garage |
| 70% | TAXI | 4 | Classic Danny DeVito sitcom set in a garage |
| 70% | GOODTIMES | 9 | 1970s sitcom set in a Chicago housing project |
| 70% | HOGANSHEROES | 12 | 1960s sitcom set in a P.O.W. camp |
| 70% | TAXI | 4 | Three-time Emmy-winning sitcom set in a garage |
| 70% | TAXI | 4 | 18-time Emmy-winning sitcom set in a garage |
| 69% | CHEERS | 6 | NBC sitcom set in a bar that starred Ted Danson |
| 69% | APBIO | 5 | Patton Oswalt sitcom set in a high-school science class |
| 67% | KIMSCONVENIENCE | 15 | Sitcom set in a corner store run by a Korean Canadian family (2016-21) |
| 67% | APBIO | 5 | Patton Oswalt sitcom set in a high-school science class (3 wds.) |
| 63% | FAMILYMATTERS | 13 | Sitcom set in Chicago that was a spin-off of "Perfect Strangers" (2 wds.) |
| 62% | SCHITTSCREEK | 12 | Sitcom set in Canada with a 2020 same-sex wedding between David and Patrick: 2 wds. |
| 60% | THEJEFFERSONS | 13 | Sitcom set in New York city that was a spin-off of "All in the Family" (2 wds.) |
| 60% | CUTAWAYGAG | 10 | Sitcom joke involving a change in setting |
| 59% | MODERN | 6 | With 35-Across, sitcom set in California with a 2014 same-sex wedding between Cameron and Mitchell |
| 58% | MADABOUTYOU | 11 | Sitcom set in New York City that featured Carol Burnett in a recurring role as Jamie's mother (3 wds.) |
| 58% | ANNE | 4 | Rice found in a bookstore |
| 57% | ROC | 3 | Sitcom set in Baltimore |