| 100% | APBIO | 5 | Sitcom set in a high school |
| 83% | APBIO | 5 | Patton Oswalt sitcom set in a high-school science class |
| 82% | APBIO | 5 | Patton Oswalt sitcom set in a high-school science class (3 wds.) |
| 73% | ABBOTTELEMENTARY | 16 | *Quinta Brunson sitcom set in a school |
| 73% | TEENWOLF | 8 | 1985 Michael J. Fox film set in a high school (2 wds.) |
| 71% | ELECTION | 8 | 1999 rom-com set in a high school featuring Reese Witherspoon and Matthew Broderick |
| 69% | CLUELESS | 8 | 1995 coming-of-age rom-com set in a high school featuring Paul Rudd and Alicia Silverstone |
| 68% | HATE | 4 | "10 Things I ___ About You," 1999 rom-com set in a high school starring Julia Stiles and Heath Ledger |
| 68% | ALLTHAT | 7 | "She's ___," 1999 rom-com set in a high school featuring Freddie Prinze Jr. and Rachael Cook: 2 wds. |
| 65% | CLUB | 4 | "The Breakfast ___" (John Hughes film set in a high-school library) |
| 64% | DAZED | 5 | "___ and Confused," 1993 comedy set in a Texan high school featuring Matthew McConaughey and Ben Affleck |
| 63% | ELLEN | 5 | Sitcom set in a bookstore |
| 63% | SANFORDANDSON | 13 | Sitcom set in a junkyard |
| 62% | CAFETERIA | 9 | Eatery in a high school |
| 61% | APBIO | 5 | Sitcom set at Whitlock High School |
| 61% | APBIO | 5 | Sitcom set in a H.S. science class |
| 61% | WASHCARS | 8 | Participate in a high school fundraiser |
| 61% | BULLY | 5 | Villain in a high school movie |
| 60% | TAXI | 4 | Tony Danza sitcom set in a garage |
| 60% | TAXI | 4 | Danny DeVito sitcom set in a garage |
| 60% | TAXI | 4 | Old sitcom set in a cab compaany |
| 60% | NIGHT | 5 | "___ Court" (rebooted sitcom set in a courtroom) |
| 60% | GHOSTS | 6 | CBS sitcom set in a haunted mansion |
| 60% | SMARTEST | 8 | Voting category in a high school yearbook |
| 60% | BOBS | 4 | "___ Burgers" (animated sitcom set in a family diner) |
| 60% | CHEERS | 6 | US television sitcom set in a Boston bar |
| 60% | TAXI | 4 | Classic Emmy-winning sitcom set in a garage |
| 60% | TAXI | 4 | Classic Danny DeVito sitcom set in a garage |
| 60% | GOODTIMES | 9 | 1970s sitcom set in a Chicago housing project |
| 60% | PEP | 3 | ___ rally (event held in a high school gym) |