| 100% | SUPERSTORE | 10 | Sitcom set in the fictional retailer Cloud 9 |
| 59% | SUPERSTORE | 10 | NBC sitcom set at fictional big-box retailer Cloud 9 in St. Louis |
| 47% | FTROOP | 6 | 1960s sitcom set in the 1860s |
| 46% | FUTURAMA | 8 | Animated sitcom set in the 31st century |
| 45% | BABBITT | 7 | Novel set in the fictional town of Zenith |
| 45% | SCOTTTUROW | 10 | Author of novels set in the fictional Kindle County |
| 44% | DIEHARD | 7 | Action film set in the fictional Nakatomi Plaza: 2 wds. |
| 44% | COCO | 4 | Pixar film set in the fictional town of Santa Cecilia |
| 44% | MAD | 3 | "___ Men," sitcom set in the competitive world of 1960s advertising |
| 44% | BLACK | 5 | "___ Panther," film series set in the fictional African nation of Wakanda |
| 44% | TROLLS | 6 | "___ Holiday," 2017 animated Christmas special set in the fictional Bergen Town |
| 43% | THEGOLDBERGS | 12 | ABC sitcom set in the 1980s narrated by 44-Across (2 wds.) |
| 42% | GREENWING | 9 | 2000s Channel 4 television comedy series set in the fictional East Hampton Hospital Trust |
| 42% | YOUNG | 5 | "___ Sheldon," sitcom set in the 1990s based on Sheldon Cooper from "The Big Bang Theory" |
| 41% | THEBURGESSBOYS | 14 | Elizabeth Strout novel set in the fictional town of Shirley Falls about two brothers (3 wds.) |
| 40% | THEROYAL | 8 | 2003-11 ITV drama series starring Amy Robbins and Wendy Craig set in the fictional town of Elsinby |
| 40% | AMYANDISABELLE | 14 | Elizabeth Strout novel set in the fictional town of Shirley Falls about a mother and daughter (3 wds.) |
| 40% | OFFICE | 6 | Sitcom set in Scranton, PA, with "The" |
| 39% | GOLDBERGS | 9 | The __, family sitcom set in 1980s Jenkintown |
| 39% | GRINCH | 6 | "The ___," 2018 animated Christmas fantasy movie set in the fictional village of Whoville |
| 39% | GREYSANATOMY | 12 | ABC's medical drama TV series starring Ellen Pompeo that is set in the fictional Seattle Grace Hospital: 2 wds. |
| 39% | THEJEFFERSONS | 13 | Sitcom set in New York city that was a spin-off of "All in the Family" (2 wds.) |
| 38% | NEWYORK | 7 | City in which the sitcom Seinfeld is set |
| 38% | TWIN | 4 | "___ Peaks," mystery series named after the fictional Washington town it is set in |
| 38% | FALLS | 5 | "Gravity ___," animated mystery show named after the fictional town it is set in |
| 38% | GAMEOFTHRONES | 13 | Fantasy drama set in the fictional continents of Westeros and Essos which will air its final season this year (2019): 3 wds. |
| 38% | ARLEN | 5 | Fictional Texas town in which "King of the Hill" is set |
| 37% | ISLANUBLAR | 10 | The fictional Central American island in Costa Rica which is the setting for 26a: 2 wds. |
| 37% | GAMBIT | 6 | "The Queen's ___," miniseries set in the 1950s based on a fictional chess prodigy |
| 37% | NORTH | 5 | "The Great ___" (animated sitcom set in Alaska) |