| 100% | REID | 4 | Spencer ___ (special agent on "Criminal Minds") |
| 74% | PRENTISS | 8 | Emily __; Criminal Minds FBI special agent |
| 59% | PAGET | 5 | Actress Brewster, Emily Prentiss on Criminal Minds |
| 53% | DEREKMORGAN | 11 | Special agent played by 39-Across on 29-Across: 2 wds. |
| 51% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title GBI special agent on 50-Across (2 wds.) |
| 49% | FED | 3 | "Criminal Minds" agent |
| 49% | FEED | 4 | *Criminal Minds agent |
| 49% | MARKHARMON | 10 | "Chicago Hope" actor who plays Special Agent Leroy Gibbs on "NCIS": 2 wds. |
| 49% | MISSYPEREGRYM | 13 | "Rookie Blues" actress who plays Special Agent Maggie Bell on "FBI" (2 wds.) |
| 49% | NIECYNASHBETTS | 14 | "Claws" actress who plays Special Agent Simone Clark on 19-Across (2 wds.) |
| 49% | REID | 4 | Spencer ___, FBI agent from "Criminal Minds" who has multiple Ph.Ds in Chemistry, Engineering, and Mathematics |
| 48% | REID | 4 | Spencer ___, character on the crime drama series "Criminal Minds" played by Matthew Gray Gubler |
| 48% | DEREK | 5 | "Criminal Minds" agent ___ Morgan |
| 48% | KYLEMACLACHLAN | 14 | "Portlandia" actor who played FBI Special Agent Dale Cooper on "Twin Peaks": 2 wds. |
| 47% | LUCASBLACK | 10 | "American Gothic" actor who plays Special Agent Christopher Lasalle on "NCIS: New Orleans": 2 wds. |
| 46% | CHRISODONNELL | 13 | "Grey's Anatomy" actor who plays Special Agent G. Callen on "NCIS: Los Angeles": 2 wds. |
| 46% | JULIANMCMAHON | 13 | "Nip/Tuck" actor who plays Supervisory Special Agent Jess LaCroix on "FBI: Most Wanted" (2 wds.) |
| 46% | UNSUB | 5 | Possible perp on "Criminal Minds" |
| 45% | TMEN | 4 | Special agents |
| 44% | REID | 4 | "Criminal Minds" agent played by Matthew Gray Gubler |
| 44% | TMAN | 4 | Special agent: Hyph. |
| 44% | DEA | 3 | Special Agent employer |
| 44% | GMAN | 4 | Special agents, informally |
| 43% | REID | 4 | "Criminal Minds" agent with an I.Q. of 187 |
| 43% | LUKEKLEINTANK | 13 | "The Man in the High Castle" actor who plays Supervisory Special Agent Scott Forrester on "FBI: International" (2 wds.) |
| 43% | SPY | 3 | Special agent like 007 |
| 43% | NARC | 4 | Agent on a bust |
| 43% | MOLE | 4 | Agent on the inside |
| 42% | AGENT | 5 | Honorific on "NCIS" or "Criminal Minds" |
| 42% | NCIS | 4 | Special Agent Gibbs's beat |