| 100% | SEAN | 4 | Spicer portrayed by Melissa McCarthy on "SNL" |
| 67% | SEAN | 4 | With 6-Down, former White House press secretary portrayed by Melissa McCarthy on "S.N.L." |
| 47% | ELNINO | 6 | Weather phenomenon portrayed by Chris Farley on SNL in October '97 |
| 45% | SNL | 3 | Show on which Melissa McCarthy plays Sean Spicer |
| 43% | URSULA | 6 | Disney villain played by Melissa McCarthy |
| 39% | SNL | 3 | NBC comedy show hosted by Melissa McCarthy five times, for short |
| 37% | COWBELL | 7 | Instrument craved by Christopher Walken on SNL |
| 37% | CESARE | 6 | Borgia portrayed by François Arnaud on "The Borgias" |
| 36% | MELISSA | 7 | McCarthy who plays Sean Spicer on "Saturday Night Live" |
| 36% | SELINAMEYER | 11 | Fictional president portrayed by Julia Louis-Dreyfus on "Veep": 2 wds. |
| 36% | MOLLYFLYNN | 10 | Title role for Melissa McCarthy on a CBS sitcom that ended May 16, 2016: 2 wds. |
| 36% | IRENE | 5 | Adler portrayed by Lara Pulver on "Sherlock" |
| 36% | TAMMY | 5 | 2014 Melissa McCarthy comedy written by McCarthy and her husband Ben Falcone |
| 35% | AHAB | 4 | "Moby Dick" captain portrayed by Patrick Stewart in a 1998 miniseries on USA |
| 35% | JADA | 4 | ___ Pinkett-Smith, who is portrayed by 1-Across in "All Eyez on Me" |
| 34% | ARTIEABRAMS | 11 | Guitarist portrayed by Kevin McHale on "Glee": 2 wds. |
| 34% | KANE | 4 | Erica portrayed by Susan Lucci on "All My Children" |
| 34% | LEAR | 4 | Shakespearean king portrayed on Broadway in 2019 by Glenda Jackson |
| 33% | DOOGIE | 6 | With 30-Across, physician portrayed by Neil Patrick Harris on a 1980s-1990s TV series |
| 33% | BILLCLINTON | 11 | President portrayed by Darrell Hammond on "Saturday Night Live": 2 wds. |
| 33% | GEORGEWBUSH | 11 | President portrayed by Will Ferrell on "Saturday Night Live": 3 wds. |
| 33% | DATA | 4 | Android portrayed by Brent Spiner on "Star Trek: The Next Generation" |
| 33% | OTERI | 5 | Cheri who portrayed Judge Judy on SNL |
| 33% | ALEC | 4 | Baldwin who portrays the Prez. on SNL |
| 33% | EMELIA | 6 | ___ Ricoletti aka "The Abominable Bride," Holmes' nemesis portrayed by Natasha O'Keeffe on BBC's "Sherlock" |
| 32% | TRAPPERJOHN | 11 | Physician portrayed by Wayne Rogers on "M*A*S*H": 2 wds. |
| 32% | FAUCI | 5 | Doctor portrayed by Brad Pitt on a 2020 "S.N.L." episode |
| 32% | MERCEDESJONES | 13 | Gospel singer portrayed by Amber Riley on "Glee": 2 wds. |
| 32% | DAVIDPALMER | 11 | Fictional president portrayed by Dennis Haysbert on "24": 2 wds. |
| 32% | ELNINO | 6 | Weather phenomenon portrayed by Chris Farley on "S.N.L." |