| 100% | HANNAHSTORM | 11 | SportsCenter anchor who was the first play-by-play announcer for the WNBA |
| 53% | SHERYLSWOOPES | 13 | Openly gay basketballer who was the first woman to be signed by the WNBA: 2 wds. |
| 49% | DRWHO | 5 | BBC classic whose title role will be played by a woman for the first time in 2017 |
| 48% | LUSIA | 5 | ___ Harris, former WNBA player who was the first and only woman ever to be officially drafted by the NBA |
| 45% | REBA | 4 | Singer McEntire who was the first woman to play Colonel Sanders |
| 45% | LORRE | 5 | Peter who was the first actor to play a Bond villain |
| 45% | MELALLEN | 8 | Announcer who was the first to call DiMaggio "Joltin' Joe" |
| 45% | DEE | 3 | Sandra who was the first to play "Gidget" |
| 44% | VAL | 3 | Basketball Hall of Famer Ackerman who was the first president of the WNBA |
| 44% | JOHNBROWN | 9 | *Abolitionist who was the first person executed for treason in the United States |
| 44% | NIMOY | 5 | Actor Leonard who was the first to play Spock |
| 44% | DEE | 3 | Actress Sandra who was the first to play Gidget |
| 44% | DEE | 3 | Actress Sandra who was the first to play "Gidget" |
| 44% | ALYN | 4 | Kirk ___, actor who was the first to play Superman |
| 44% | ALEC | 4 | Baldwin who was the first to play Jack Ryan |
| 44% | IRA | 3 | Aldridge who was the first Black actor to play Othello |
| 44% | AVA | 3 | Director DuVernay who was the first African American woman nominated for a Best Picture Oscar |
| 43% | ALEC | 4 | Actor Guinness who was the first to play Obi-Wan Kenobi |
| 43% | TOBEY | 5 | Actor Maguire who was the first to play Spider-Man in movies |
| 43% | BRYANT | 6 | Kobe ___, former Los Angeles Lakers player who was the first guard to play 20 seasons in NBA |
| 43% | AVA | 3 | Director DuVernay who was the first African-American woman nominated for a Best Picture Oscar |
| 42% | EDITH | 5 | Wharton who was the first woman to win the Pulitzer Prize for Literature |
| 42% | EDITH | 5 | Wharton who was the first woman to win a Pulitzer Prize for fiction |
| 42% | LUISE | 5 | Rainer who was the first person to win two Academy Awards for acting |
| 42% | ANGELA | 6 | Bassett who was the first person to be nominated for an Oscar for acting in a Marvel movie |
| 42% | GEOFFREYRUSH | 12 | "Shine" star who was the first Australian to be nominated for Oscars in two acting categories (2 wds.) |
| 42% | DIANA | 5 | Taurasi who was the first WNBA player to score more than 9,000 points |
| 42% | RHYNEHOWARD | 11 | University of Kentucky guard who was selected by the Atlanta Dream as the first overall pick in the 2022 WNBA draft (2 wds.) |
| 42% | STEVEN | 6 | Yeun who was the first Asian American nominated for Best Actor (2020's "Minari") |
| 42% | TJWARD | 6 | Safety drafted by the Browns in 2010 who played for the Broncos in 2014-17 and is god-brother to Maurice Jones-Drew |