| 100% | ILLINOIS | 8 | Springfield's state which became the first state to decriminalize same-sex relations in 1962 |
| 46% | DENMARK | 7 | Copenhagen's country which was the first country to legally recognize registered same-sex couples in 1989 |
| 37% | PONCEDELEON | 11 | Explorer who in 1513 became the first European to set foot in 14-Across, and gave the state its name: 3 wds. |
| 36% | SHERYL | 6 | I wrote "Lean In" and became the first woman to join Facebook's board of directors |
| 35% | RADIO | 5 | In 1922, Warren G. Harding became the first U.S. president to be broadcast over this |
| 35% | ALABAMA | 7 | Montgomery's state that was the first US state to recognize Christmas as a holiday in 1836 |
| 35% | ORANGUTANS | 10 | In 2014 Argentina became the first country to recognize these primates' legal rights |
| 35% | ELMO | 4 | He became the first puppet to testify before Congress in 2002 |
| 35% | WARRENGHARDING | 14 | U.S. president who, in 1922, became the first president to have his voice transmitted on the radio (3 wds.) |
| 35% | APRIL | 5 | Month in 2021 when NASA's Ingenuity became the first powered aircraft to fly on Mars |
| 34% | GIRL | 4 | ___ Named Tom, musical group that became the first trio to win "The Voice" in 2021 |
| 34% | SARAHPALIN | 10 | In 2006, she became the first woman to be elected governor of Alaska: 2 wds. |
| 34% | JESMYNWARD | 10 | In 2017, she became the first woman to win two National Book Awards for fiction |
| 34% | LAIKA | 5 | Dog who became the first living being to orbit the Earth in 1957 |
| 34% | VALENTINA | 9 | ___ Tereshkova, cosmonaut who became the first woman to fly in space in 1964 |
| 34% | HIJAB | 5 | Halima Aden became the first Sports Illustrated model to wear one in 2019 |
| 34% | EGGTOSS | 7 | Game in which the first player to crack loses? |
| 34% | ITO | 3 | In 1981, she became the first woman to land a triple-triple jump combination in competition |
| 34% | SUSANAMARTINEZ | 14 | In 2010, she became the first woman to be elected governor of New Mexico: 2 wds. |
| 34% | NIKKIHALEY | 10 | In 2010, she became the first woman to be elected governor of South Carolina: 2 wds. |
| 34% | IONE | 4 | Girl's name in which the last three letters are equivalent to the first? |
| 34% | GIBB | 4 | Bobbi, who in 1966 became the first woman to run the entire Boston Marathon |
| 34% | XGAMES | 6 | 2013 competition where Mitchie Brusco became the first person to land a 1080 at in the Big Air event |
| 34% | MANNYPACQUIAO | 13 | Filipino boxer who recently became the first person to hold a world title in four different decades: 2 wds. |
| 33% | KALPANA | 7 | ___ Chawla, American astronaut who became the first Indian woman to fly in space in 1997 |
| 33% | SALLY | 5 | ___ Ride, American astronaut who became the first American woman to fly in space in 1983 |
| 33% | WARRIORS | 8 | Basketball team that moved from Philadelphia to the Golden State's Bay Area in 1962 |
| 33% | WILMA | 5 | Considered the world's fastest woman in the 60s, she became the first American woman to win three golds in a single Olympic Games |
| 33% | YENTL | 5 | Film for which Barbra Streisand became the first woman to win a Golden Globe for directing |
| 33% | WHITSON | 7 | Peggy ___, American astronaut who became the first woman to command the International Space Station in 2007 |