| 100% | PLAME | 5 | Spy played by Watts in ''Fair Game'' |
| 55% | PEEL | 4 | Spy played by Diana Rigg in TV's "The Avengers" |
| 52% | JOHNNYENGLISH | 13 | Inept British spy played by 49-Across in three films (2 wds.) |
| 51% | ETHANHUNT | 9 | Fictional spy played by Tom Cruise in "Mission: Impossible" film series: 2 wds. |
| 51% | ANN | 3 | ___ Darrow, character played by Naomi Watts in "King Kong" |
| 51% | ALAN | 4 | Turing played by Benedict Cumberbatch in "The Imitation Game" |
| 51% | CHESS | 5 | Game played by Alice in "Through the Looking-Glass" |
| 51% | ALAN | 4 | Turing played by Benedict Cumberbatch in “The Imitation Game” |
| 50% | JOHNNYENGLISH | 13 | Inept British spy played by 15-Across who "Strikes Again" in 2018 (2 wds.) |
| 50% | ALAN | 4 | Mathematician Turing played by Benedict Cumberbatch in "The Imitation Game" |
| 50% | JAMESBOND | 9 | British spy played by 33-Across for the first time in 48-Across (2 wds.) |
| 49% | ALAN | 4 | Computing pioneer Turing played by Benedict Cumberbatch in "The Imitation Game" |
| 49% | ALMA | 4 | President Coin played by Julianne Moore in two "Hunger Games" films |
| 48% | JAMESBOND | 9 | British spy played by 31-Across in 1969's "On Her Majesty's Secret Service" (2 wds.) |
| 48% | ELIZA | 5 | & 11D Character played by Audrey Hepburn in 1964 film musical My Fair Lady |
| 48% | POOHSTICKS | 10 | Game played by Tigger and Eeyore in the Hundred Acre Wood |
| 47% | HEATHERLEE | 10 | Character played by Alicia Vikander in the action spy movie "Jason Bourne": 2 wds. |
| 47% | GALEHAWTHORNE | 13 | Fictional archer played by Liam Hemsworth in "The Hunger Games: Catching Fire": 2 wds. |
| 46% | BACCARAT | 8 | Casino game played by James Bond in a novel |
| 46% | ENDER | 5 | Game player Wiggin played by Asa Butterfield in 2013 |
| 46% | MATAHARI | 8 | Spy played by Greta Garbo |
| 46% | BOND | 4 | Spy played by Daniel Craig |
| 44% | BLACKJACK | 9 | Card game played by Tom Cruise and Dustin Hoffman in "Rainman" |
| 44% | GINRUMMY | 8 | Card game played by Matt Dillon in "The Flamingo Kid" (2 wds.) |
| 44% | MARGAERY | 8 | Tyrell daughter played by Natalie Dormer in "Game of Thrones" |
| 44% | CERSEI | 6 | Lannister sister played by Lena Headey in "Game of Thrones" |
| 44% | JON | 3 | ___ Snow, character played by Kit Harington in "Game of Thrones" |
| 44% | NED | 3 | Role played by Sean Bean in "Game of Thrones," fondly |
| 43% | PYGMALION | 9 | Play written in 1912 by George Bernard Shaw that was adapted into the film "My Fair Lady" |
| 43% | MAXWELLSMART | 12 | TV spy played by Don Adams |