| 100% | RICHARDLEWIS | 12 | Stand-up comedian who plays a fictionalized version of himself on "Curb Your Enthusiasm" (2 wds.) |
| 91% | WANDASYKES | 10 | Stand-up comedian who plays a fictionalized version of herself on "Curb Your Enthusiasm" (2 wds.) |
| 80% | LARRYDAVID | 10 | "Seinfeld" co-creator who plays a fictionalized version of himself on "Curb Your Enthusiasm" (2 wds.) |
| 62% | JERRYSEINFELD | 13 | Comedian who played a fictional version of himself on a sitcom about "nothing" (2 wds.) |
| 54% | LARRYDAVID | 10 | Actor and comedian who created HBO's comedy series "Curb Your Enthusiasm" and stars in it as a fictionalized version of himself: 2 wds. |
| 46% | JOHNMULANEY | 11 | Stand-up comedian who guest-stars as Stevie on a 2023 flashback episode of "The Bear": 2 wds. |
| 45% | ESAIMORALES | 11 | "NYPD Blue" actor who plays a waiter who may have committed credit card fraud on Season 10 of "Curb Your Enthusiasm" (2 wds.) |
| 44% | FREDDIEPRINZE | 13 | Stand-up comedian who played young mechanic Chico on "Chico and the Man": 2 wds. |
| 44% | WILLSMITH | 9 | Actor who starred as a fictionalized version of himself in the hit TV series "The Fresh Prince of Bel-Air": 2 wds. |
| 44% | NYE | 3 | "Science Guy" Bill who plays a fictional version of himself on "Blindspot" |
| 43% | FLIPWILSON | 10 | Stand-up comedian who played Geraldine on his Emmy-winning variety show from 1970 to 1974: 2 wds. |
| 42% | PATRICKHARRIS | 13 | Neil ___, actor who made a cameo in "Harold & Kumar go to White Castle" by playing a fictionalized version of himself: 2 wds. |
| 41% | CAROLBURNETT | 12 | Emmy-winning comedian who played a clumsy woman with a guardian angel on "The Twilight Zone": 2 wds. |
| 41% | DANADELANY | 10 | "China Beach" actress who played a medical examiner on "Body of Proof": 2 wds. |
| 41% | RICHARDKIND | 11 | "Curb Your Enthusiasm" actor who played press secretary Paul Lassiter on 45-Across (2 wds.) |
| 40% | JIM | 3 | "The ___ Gaffigan Show," TV series starring stand-up comedian Gaffigan as a fictionalized version of himself |
| 39% | CARLOSVALDES | 12 | Actor who plays Cisco Ramon on "The Flash" which is a part of the Arrowverse: 2 wds. |
| 38% | SUSIEESSMAN | 11 | Actress who plays the foul-mouthed wife of the main character's manager Jeff on "Curb Your Enthusiasm": 2 wds. |
| 38% | LARRYDAVID | 10 | "Curb Your Enthusiasm" star who gave his Prius to a medical student in 2006: 2 wds. |
| 38% | VINCEVAUGHN | 11 | "True Detective" actor who plays a friend who knows an inventor who can help Larry in Season 10 of "Curb Your Enthusiasm" (2 wds.) |
| 38% | CHERYLHINES | 11 | Actress who plays the main character's ex-wife on "Curb Your Enthusiasm": 2 wds. |
| 37% | HOWIEMANDEL | 11 | Former stand-up comedian and "St. Elsewhere" actor who has been a judge on "America's Got Talent" since 2010 (2 wds.) |
| 37% | TRACEYULLMAN | 12 | "Into the Woods" actress who played Princess Winnifred in the 2005 made-for-TV version of "Once Upon a Mattress": 2 wds. |
| 37% | ZACHARYLEVI | 11 | "Chuck" actor who plays the grown-up superhero version of 38-Across in "Shazam!": 2 wds. |
| 37% | LAURIEMETCALF | 13 | Actress whose real-life daughter played a younger version of her character on "Roseanne": 2 wds. |
| 37% | HOPEDAVIS | 9 | "Wayward Pines" actress who plays the wife of a mob boss on 54-Across (2 wds.) |
| 37% | WILLFORTE | 9 | Former Groundlings comedian who played MacGruber on "SNL": 2 wds. |
| 37% | JAMESBROLIN | 11 | Actor who played a physician on 28-Across: 2 wds. |
| 36% | KRISTENWIIG | 11 | Former Groundlings comedian who played Target Lady on "SNL": 2 wds. |
| 36% | SASHEERZAMATA | 13 | 30-Down actress who plays a journalist on "Woke": 2 wds. |