| 100% | FRONTIER | 8 | Star Trek opening: Space, the final __ |
| 65% | SPACE | 5 | The final frontier, per the opening of "Star Trek" |
| 61% | SPACE | 5 | "The final frontier" in the opening narration of "Star Trek" |
| 59% | FRONTIER | 8 | The Final __; subtitle of Star Trek V |
| 53% | SPACE | 5 | The final frontier, per "Star Trek" |
| 51% | SPACE | 5 | "___, the final frontier" ("Star Trek" monologue opener) |
| 47% | FRONTIER | 8 | Space: the final this |
| 45% | WRATH | 5 | Star Trek II: The ___ of Kahn |
| 45% | SPACE | 5 | First word in the “Star Trek” opening-credits monologue |
| 45% | COCOGAUFF | 9 | 18-year-old American tennis star who lost to Iga Swiatek in the 2022 French Open final: 2 wds. |
| 45% | STARFLEET | 9 | Star Trek captains report to this space force |
| 44% | NEMESIS | 7 | Star Trek: __, film with Tom Hardy as the villain |
| 44% | TNG | 3 | Star Trek: The Original Series spin-off before DS9 |
| 44% | SPACE | 5 | "The final frontier," per "Star Trek" |
| 44% | ANGELA | 6 | "Mission: Impossible -- The Final Reckoning" star Bassett |
| 44% | WIDE | 4 | "___ Open Spaces" (1998 hit song by The Chicks) |
| 43% | VOYAGER | 7 | 1990s Star Trek TV series, NASA space mission |
| 43% | COLM | 4 | "Star Trek: Deep Space Nine" star Meaney |
| 43% | WESLEY | 6 | Youngest Crusher in Star Trek: The Next Generation |
| 43% | TROI | 4 | Counselor Deanna on Star Trek: The Next Generation |
| 43% | LEVAR | 5 | "Star Trek: The Next Generation" star Burton |
| 42% | MORN | 4 | The only Lurian to appear in "Star Trek: Deep Space Nine" |
| 42% | HAS | 3 | Third-to-last word of the "Star Trek" opening speech |
| 42% | TROI | 4 | Picard's counselor on Star Trek: The Next Generation |
| 41% | YOSEMITE | 8 | California national park featured in "Star Trek V: The Final Frontier" |
| 41% | JAMESKIRK | 9 | The Star Trek character played by William Shatner |
| 41% | CARELL | 6 | Star of the Netflix series Space Force: Steve __ |
| 40% | PROSPER | 7 | On Star Trek, completes the phrase "Live Long and" |
| 40% | DEATHSTAR | 9 | The Empire's massive space station from Star Wars |
| 40% | ADES | 4 | Open cluster of stars in the solar system: Hy___ |