| 100% | TITANIC | 7 | Subject of Walter Lord's "A Night to Remember" |
| 48% | LORETTA | 7 | Young of "A Night to Remember" |
| 46% | MATH | 4 | Subject of debate as to whether or not it’s a science |
| 44% | GENE | 4 | Subject of interest to a 23andMe user |
| 44% | ORDER | 5 | Subject of a phone call to a pizzeria |
| 43% | OLDMACDONALD | 12 | Subject of a children's song associated with the vowels in the answer to each starred clue |
| 42% | ALZARQAWI | 9 | Subject of the 2008 book "How to Break a Terrorist" |
| 42% | ABCS | 4 | Subject of a book that goes from apple to zebra |
| 41% | BETATESTED | 10 | Subjected to a round of end-user evaluation |
| 40% | HIPPOLYTA | 9 | Queen of the Amazons betrothed to Theseus in William Shakespeare play A Midsummer Night's Dream |
| 40% | BREXIT | 6 | Subject of a 2016 U.K. referendum, and a hint to five puzzle answers |
| 40% | ATOZ | 4 | Full range of facts related to a subject |
| 40% | SHEEP | 5 | Subject of a late-night countdown |
| 39% | JUDGECRATER | 11 | Subject of a 1930's mystery |
| 39% | YOYO | 4 | Subject of a 1930's fad |
| 39% | WHITEWATER | 10 | Subject of a 1990's probe |
| 39% | NAG | 3 | Subject of a tipster's tip |
| 39% | WIFI | 4 | Subject of a houseguest's query |
| 39% | H&RBLOCK | 8 | Subject of the Final Jeopardy! question that knocked out Ken Jennings after a record 74 wins ... or a hint to this puzzle's theme |
| 39% | FOMO | 4 | Reason to hit the town on a Friday night instead of staying home in your p.j.’s |
| 39% | OPIOID | 6 | Subject of a U.S. drug epidemic |
| 39% | REDSKY | 6 | Subject of a sailor's weather maxim |
| 39% | LICE | 4 | Subject of a school nurse's inspection |
| 39% | IDES | 4 | Subject of a Shakespearean soothsayer's warning |
| 39% | LOVE | 4 | Subject of a Valentine's Day card |
| 39% | TIME | 4 | Subject of a marathoner's P.R. |
| 38% | BIRDSANDBEES | 12 | Subject of "the talk" about sex … or a hint to the answers to the four starred clues |
| 38% | BREXIT | 6 | Subject of a 2016 U.K. referendum ... or a hint to 16-, 25-, 41- and 55-Across |
| 38% | EVE | 3 | Night to remember, perhaps |
| 38% | ODE | 3 | A lyric poem in the form of an address to a particular subject |