| 100% | OLOGY | 5 | Suffix of science branches as in bio and psych |
| 40% | GEOLOGY | 7 | Branch of science that deals with the study of earth as well as its structure and composition |
| 36% | PHYSICS | 7 | Branch of science covering gravity and magnetism |
| 36% | ALCHEMY | 7 | Branch of science Nicholas Flamel worked in |
| 36% | ICS | 3 | Suffix in the names of many sciences |
| 35% | ECOLOGY | 7 | Branch of science dealing with organisms and their environment |
| 34% | BIO | 3 | Science that anatomy and zoology are branches of, for short |
| 33% | ORLANDO | 7 | Brother of Oliver and Jacques in As You Like It |
| 33% | SMACK | 5 | With 33-Down, precisely, as in the middle of 17-, 23-, 51- and 62-Across |
| 33% | BOTANY | 6 | Branch of science that deals with the study of plants and their classification |
| 32% | SHIA | 4 | Branch of Islam that predominates in Iran and Iraq |
| 32% | TEDTALKS | 8 | Videos such as "The Power of Vulnerability" and "The Science of Illusion" |
| 32% | DEINO | 5 | Sister of Enyo and Pemphredo in Greek mythology also known as Dino |
| 31% | OYER | 4 | Court of ___ and Terminer, as created for the Salem witch trials in 1692 |
| 31% | ELIDE | 5 | Skip, as the "f" and "the" in "two of the clock" |
| 31% | PHYSICS | 7 | Branch of science concerned with the study of the properties of space, time, matter and energy |
| 31% | BIRDS | 5 | There are two, as the expression goes, in each of 16- and 55-Across |
| 31% | WELSH | 5 | Language in which "dd" and "ff" are treated as single letters of the alphabet |
| 31% | OFFCENTER | 9 | Out of whack, as shown in 18-, 24-, 41- and 51-Across |
| 31% | DICK | 4 | Philip K —, author of science fiction novels The Man in the High Castle and The Game-Players of Titan |
| 31% | SHIA | 4 | Branch of Islam predominant in Iran and Iraq |
| 31% | BIOETHICS | 9 | Study of morality in medicine and life sciences |
| 30% | SERPENT | 7 | Speaker of the words "Ye shall be as gods, knowing good and evil," in Genesis |
| 30% | WHISTLETONE | 11 | Extremely high vocal register, as heard in the music of Mariah Carey and Ariana Grande |
| 30% | ARTWORLD | 8 | Arena of activism for Nan Goldin, as documented in “All the Beauty and the Bloodshed” |
| 30% | BONE | 4 | Former name, under French rule, of the city and port in Algeria known now as Annaba |
| 30% | TRANSFORMERS | 12 | Film franchise starring 46-Across as Cade Yeager in "Age of Extinction" and "The Last Knight" |
| 30% | VICTORIAN | 9 | Architectural style characterized by steep roofs and grand staircases, as seen in the Palace of Westminster |
| 30% | PHYSICS | 7 | Branch of science that studies matter and the fundamentals of the universe, popularized by Niels Bohr and Richard Feynman |
| 30% | NEO | 3 | Hero of three science fiction movies in 1999 and 2003 |