| 100% | VISION | 6 | Superhero co-created by 41-Across and played by Paul Bettany |
| 77% | FALCON | 6 | Superhero co-created by 41-Across and played by Anthony Mackie |
| 76% | DOCTORSTRANGE | 13 | Superhero co-created by 41-Across and played by Benedict Cumberbatch (2 wds.) |
| 76% | IRONMAN | 7 | Superhero co-created by 41-Across and played by Robert Downey Jr. (2 wds.) |
| 46% | VISION | 6 | Marvel hero played by Paul Bettany |
| 45% | ANTMAN | 6 | Superhero played by Paul Rudd |
| 44% | BATWOMAN | 8 | The CW superhero played by 15-Across and 29-Across |
| 43% | ANT | 3 | "___ -Man," superhero played by Paul Rudd |
| 43% | ANTMAN | 6 | Marvel superhero played by Paul Rudd |
| 43% | ANT | 3 | ___-Man (Marvel superhero played by Paul Rudd) |
| 43% | ANTMAN | 6 | Insect-sized superhero played by Paul Rudd |
| 43% | ANTMAN | 6 | Shrinking superhero played by Paul Rudd: Hyph. |
| 42% | BERNIETAUPIN | 12 | Lyricist and frequent 17-Across collaborator played by Jamie Bell in 41-Across (2 wds.) |
| 42% | SPIDERMAN | 9 | Superhero played by Garfield, Holland and Maguire |
| 42% | ELTONJOHN | 9 | Rock superstar and frequent 27-Across collaborator played by Taron Egerton in 41-Across (2 wds.) |
| 42% | NURSERATCHED | 12 | Villain created by Ken Kesey played by 19-Across and 34-Across (2 wds.) |
| 41% | JESSESTONE | 10 | Fictional detective created by novelist 33-Across and played by actor 43-Across (2 wds.) |
| 40% | FANTASTICFOUR | 13 | Group of superheroes created by Jack Kirby and Stan Lee (2 wds.) |
| 40% | THEXMEN | 7 | Group of superheroes created by Jack Kirby and Stan Lee (2 wds.) |
| 40% | THEAVENGERS | 11 | Group of superheroes created by Jack Kirby and Stan Lee (2 wds.) |
| 40% | BRIAN | 5 | Singer Wilson played by Paul Dano and John Cusack in "Love & Mercy" |
| 40% | BASS | 4 | Instrument played by rockers Flea and Paul McCartney |
| 40% | MIKEHAMMER | 10 | Private investigator created by Mickey Spillane played by 43-Across in the 1980s and 1990s (2 wds.) |
| 40% | POPE | 4 | "Battle ___," independent superhero comic book series created by Robert Kirkman and Tony Moore |
| 39% | ANTONCHEKHOV | 12 | Russian writer who created the characters played by 15-Across, 40-Across, and 45-Across in "The Seagull" |
| 39% | SUPERMAN | 8 | Fictional superhero from DC Comics which was created by Jerry Siegel and Joe Shuster |
| 39% | NEWYEARS | 8 | With 16-Across, December 31 celebratory program created by 43-Across and now co-hosted by Ryan Seacrest and 26-Down (2 wds.) |
| 39% | MARENGHI | 8 | Garth —, comedy character co-created and played by Matthew Holness, winner of the 2001 Perrier Award at the Edinburgh Festival Fringe |
| 39% | ANT | 3 | ___-Man (superhero played by Paul Rudd) |
| 38% | AMERICA | 7 | Fictional superhero Captain ___ from Marvel Comics which was created by Joe Simon and Jack Kirby |