| 100% | KOOP | 4 | Surgeon General under Reagan, who surprised both parties with his efforts to fight AIDS and smoking |
| 26% | KOOP | 4 | Surgeon general under Reagan |
| 23% | HUSTON | 6 | John who directed both his father, Walter, and his daughter, Anjelica, to Oscar wins |
| 22% | TIMOTHYBRADLEY | 14 | Former boxer with five world titles who followed a vegan diet for his fights from 2008 to 2015: 2 wds. |
| 22% | TYLER | 5 | With 32-Across, entertainment mogul who partnered with Oprah to bring his series "The Haves and the Have Nots" to OWN in 2013 |
| 22% | BRITNEYSPEARS | 13 | "Slumber Party" singer who is the youngest person to be both host and musical guest on "Saturday Night Live" (2 wds.) |
| 22% | BARR | 4 | Attorney general under both Bush 41 and Trump |
| 22% | KICKBOX | 7 | Fight with both fists and feet |
| 22% | HARLANCOBEN | 11 | Mystery writer who signed a five-year deal with Netflix to develop 14 of his novels as miniseries and films (2 wds.) |
| 21% | KICKBOXER | 9 | One who fights with fists and feet |
| 21% | AMBI | 4 | Prefix with "dextrous" to mean someone who uses both left and right hand with equal ease |
| 21% | LEN | 3 | Irish mythological figure who lived under a loch near Killarney and flung his anvil into the hills each night causing pearls of rain to fall |
| 21% | SCHUMACHER | 10 | Retired German F1 racing driver who shares his first name with 31a, and according to Forbes is the fifth highest-paid athlete of all time |
| 21% | POET | 4 | Expert who works with both feet and meters? |
| 20% | BENEDICT | 8 | "The Fifth Estate" actor who was pranked by a movie crew and asked to dot his face with a "neuron cream" as a shield against radiations |
| 20% | WERELOST | 8 | With 68- and 97-Across, his comment while driving to Cooperstown |
| 20% | HEAVY | 5 | With 2-Down, phrase applicable to both iron and Iron Maiden |
| 20% | MICHELLE | 8 | With 43-Across, actress who's played both Catwoman and the Wasp |
| 20% | MRT | 3 | Actor who played Santa with Nancy Reagan in his lap |
| 20% | MILLER | 6 | Lee __, who worked with Man Ray and was his muse |
| 20% | GEAR | 4 | With 23-Across, one who might be excited to look under a hood |
| 19% | BERRA | 5 | Manager who led both the Yankees and Mets to pennants |
| 19% | EDMEESE | 7 | Attorney general under Reagan |
| 19% | MEESE | 5 | Attorney General under Reagan |
| 19% | STEWIE | 6 | Animated-sitcom baby who both kills and is killed by his own mother |
| 19% | SELENAGOMEZ | 11 | "Hands to Myself" singer who records in both English and Spanish: 2 wds. |
| 19% | ERIC | 4 | ___ Friedman, guitarist and backing vocalist who toured with "Creed" from 2009 to 2012 |
| 19% | UNI | 3 | Prefix with "sex" to mean suitable for both male and female |
| 19% | SHERMAN | 7 | General who gave his name to a Giant Sequoia |
| 19% | GOTYE | 5 | His "Somebody That I Used to Know" topped both the Hot 100 and Alternative Airplay charts |