| 100% | HALTWHOGOESTHERE | 16 | Surprise surprise! Whom should walk in? Just my best friend ever! |
| 39% | PUMBAA | 6 | Timon's best friend in "The Lion King" who once sang, "And it hurt that my friends never stood downwind..." |
| 38% | RUPERTEVERETT | 13 | "My Best Friend's Wedding" actor who plays older Patrick Hazelwood in "My Policeman" (2 wds.) |
| 36% | ASYOUCATSLIKEIT | 15 | *"This should be just right, my furry friends"? |
| 35% | ASYOUCATSLIKEIT | 15 | *"This should be just right, my furry friends"? |
| 35% | ALAN | 4 | Barbie's boyfriend's best friend who was introduced in 1964 |
| 34% | NED | 3 | Leeds who is Spider-Man's best friend in the MCU movies |
| 34% | LILO | 4 | ___ Pelekai who's Stitch's best friend in a Disney animated franchise |
| 34% | OCASEK | 6 | Ric who wrote the hit song "My Best Friend's Girl" |
| 33% | KEITH | 5 | ___ Urban who sang "You Look Good in My Shirt" |
| 32% | OPRAH | 5 | Winfrey who said "I still have my feet on the ground, I just wear better shoes" |
| 32% | WEST | 4 | Kanye ___, rapper who won the Grammy Award for Best Rap Song in 2005 for "Jesus Walks" |
| 32% | GUS | 3 | Mouse who was best friends with the protagonist in the 1950 animated musical fantasy film "Cinderella" |
| 32% | DAVE | 4 | ___ Coulier, who played Joey Gladstone, Jesse and Danny's best friend in the 1987 sitcom "Full House" |
| 31% | ANDREABARBER | 12 | Actress who played Kimmy Gibbler, D.J's best friend in the 1987 sitcom "Full House:" 2 wds. |
| 31% | SPEAKOFTHEDEVIL | 15 | "Well, looky who just came in!" |
| 31% | DONKEY | 6 | Shrek's best friend in "Shrek" who once said, "Because that's what friends do. They forgive each other" |
| 30% | WOODY | 5 | Buzz Lightyear's best friend in "Toy Story" who features in the song "You've Got a Friend in Me" |
| 30% | LIZZYCAPLAN | 11 | "Masters of Sex" actress who plays one of Toby Fleishman's best friends on "Fleishman Is in Trouble" (2 wds.) |
| 30% | EVERETT | 7 | Rupert __, My Best Friend's Wedding actor |
| 30% | BETTEMIDLER | 11 | "Wind Beneath My Wings" singer who won the Best New Artist Grammy in 1974: 2 wds. |
| 30% | DOG | 3 | Man's best friend ... who's also the contestant featured in the sports mentioned in 19a, 23a, 35a, 4d, 7d, 40d |
| 29% | ROBERTALTMAN | 12 | Five-time Best Director nominee who said "All of the best things in my films are mistakes" |
| 29% | DEBBYBOONE | 10 | "You Light Up My Life" singer who won the Best New Artist Grammy in 1978: 2 wds. |
| 29% | CHANDLER | 8 | Best friend to Ross in Friends |
| 29% | FWIW | 4 | Just my opinion, in a tweet |
| 29% | CYNDILAUPER | 11 | "Girls Just Wanna Have Fun" singer who won the Grammy for Best New Artist in 1985: 2 wds. |
| 29% | NOSYBESTIE | 10 | Good friend who won't stop snooping? |
| 29% | STARTREKII | 10 | Movie in which Ricardo Montalban says, "Kirk, my old friend, do you know the Klingon proverb ... 'Revenge is a dish best served cold'?" |
| 28% | PAIGE | 5 | Whom DiMaggio called ''the best I ever faced'' |