| 100% | LIA | 3 | Swimmer Thomas who became the first openly trans athlete to win an N.C.A.A. Division I national championship (March, 2022) |
| 52% | LIA | 3 | ___ Thomas, first openly transgender athlete to win an NCAA Division I national championship (swimming) |
| 34% | ELLIOT | 6 | Page who became the first openly trans man to appear on the cover of Time magazine (2021) |
| 32% | ALTHEAGIBSON | 12 | In 1957, she became the first person of color to win a Wimbledon championship (2 wds.) |
| 32% | ALTHEAGIBSON | 12 | Tennis great who was the first person of color to win a Wimbledon championship (2 wds.) |
| 31% | LIN | 3 | Jeremy who was the first Asian American to win an NBA Championship |
| 31% | CHLOEZHAO | 9 | 16-Across director who won an Academy Award for Best Director in 2021, becoming the first non-white woman to win a directing Oscar (2 wds.) |
| 31% | EVELYNASHFORD | 13 | The first track and field athlete to run 100 meters under 11 seconds in an Olympic Games and who has won a total of 5 Olympic medals: 2 wds. |
| 31% | CARDI | 5 | ___ B, hip hop star who became the first female rapper to win a Grammy for Best Rap Album |
| 31% | EMMA | 4 | Raducanu who recently became the first qualifier to win a Grand Slam singles final |
| 30% | DANICAPATRICK | 13 | Racing great who became the first woman driver to win an Indy car race in April 2008 (2 wds.) |
| 30% | RAMIMALEK | 9 | Actor who became the first one of Egyptian heritage to win an Oscar for Best Actor in 2019: 2 wds. |
| 30% | JOCELYNALO | 10 | Softball player who won two National Championships with the Oklahoma Sooners and who was honored with a Best College Athlete, Women's Sports ESPY Award in 2022 (2 wds.) |
| 30% | LUPITANYONGO | 12 | "12 Years a Slave," 18-Across, and 32-Across star who was the first Kenyan-Mexican actress to win an Oscar (2 wds.) |
| 30% | DAWES | 5 | American gymnast Dominique who was the first Black athlete to win an Olympic gold medal in gymnastics |
| 29% | DEBBIE | 6 | ___ Armstrong, former alpine skier who was the first female American skier to win an Olympic gold medal |
| 29% | JACKIESTILES | 12 | 2016 Women's Basketball Hall of Fame inductee who was the first Division I player to score over 1,000 points in a season: 2 wds. |
| 28% | ALTHEA | 6 | Gibson who was the first person of color to win a tennis Grand Slam event |
| 28% | TONYDUNGY | 9 | Hall-of-Famer who was the first Black head coach to win a 15 Across |
| 28% | GEORGIA | 7 | Team that defeated 15-Across to win the 2022 College Football Playoff National Championship, its first national title since 1980 |
| 28% | ANNMEYERS | 9 | Basketball Hall-of-Famer who was the first woman to sign an N.B.A. contract |
| 28% | HARLANCOBEN | 11 | 17-Across and 30-Across novelist who is the first writer to win an Anthony Award, a Shamus Award, and an Edgar Award (2 wds.) |
| 28% | BOBBYKNIGHT | 11 | Hoops coach with the most N.C.A.A. Division I wins |
| 28% | BASIE | 5 | Jazz great who was the first African-American man to win a Grammy |
| 27% | TEBOW | 5 | Tim who was the first sophomore to win a Heisman |
| 27% | ALI | 3 | Mahershala who was the first Muslim performer to win an Oscar |
| 27% | ALI | 3 | Mahershala who was the first Muslim actor to win an Oscar |
| 27% | SALONGA | 7 | Lea who was the first Asian actress to win a Tony |
| 27% | IRA | 3 | Songwriter Gershwin who was the first lyricist to win a Pulitzer |
| 27% | GINNI | 5 | She is an American business leader who became the first woman to head tech giant IBM |