| 100% | ENDOCRINE | 9 | System for the hormonal |
| 67% | ASL | 3 | System for the deaf, for short |
| 66% | BRAILLE | 7 | Reading system for the blind |
| 65% | ASL | 3 | Communication system for the deaf: Abbr. |
| 64% | ASL | 3 | Communication system for the deaf, for short |
| 64% | ASL | 3 | Communication system for the gorilla Koko: Abbr. |
| 64% | ASL | 3 | Communication system for the hearing-impaired: Abbr. |
| 64% | ASL | 3 | "Talking" system for the deaf, in brief |
| 64% | BRAILLE | 7 | Raised dot writing system for the blind |
| 64% | ASL | 3 | Communication system for the hearing-impaired (Abbr.) |
| 62% | PITTSBURGHPA | 12 | System for broadcasting across the Allegheny? |
| 60% | BRAIN | 5 | Command center for the nervous system |
| 60% | METRO | 5 | Another word for the subway system |
| 60% | ZINC | 4 | Essential nutrient for the immune system |
| 60% | BASE | 4 | Two, for the binary number system |
| 60% | RADIX | 5 | 10, for the base 10 system |
| 59% | MOON | 4 | William —, 19th-century inventor of a writing system for the blind |
| 59% | RADIX | 5 | 10, for the base 10 number system |
| 58% | DEWEY | 5 | Melvil —, US inventor of a system for the classification of library books |
| 58% | DOWNWARD | 8 | Asana for the immune system and the mind |
| 58% | RADIX | 5 | This is 20 for the vigesimal number system |
| 57% | WOOFER | 6 | Loudspeaker used in hi-fi systems for the reproduction of low audio frequencies |
| 57% | PROBIOTIC | 9 | A bacteria or yeast good for the digestive system |
| 57% | DIGESTIVE | 9 | The organ system responsible for processing food |
| 53% | ROTATION | 8 | System used for the plantation in Middle Ages |
| 52% | CHATGPT | 7 | OpenAI system that wrote the clue for 8-Across |
| 52% | TERMINATOR | 10 | Shorter name for the Cyberdyne Systems Model 101, apparently still operating after 35 years |
| 51% | ASL | 3 | System in which "time" is a tap on the wrist, for short |
| 51% | JUPITER | 7 | Planet in the solar system known for its Red Spot |
| 51% | TUBE | 4 | The ___ (nickname for the London subway system) |