| 100% | GERALDORIVERA | 13 | Tabloid talk-show host (1987-1998) whose nose was broken in an on-air brawl (2 wds.) |
| 44% | DRPHIL | 6 | Daytime talk show host whose surname is McGraw: 2 wds., abbr. |
| 44% | DREWBARRYMORE | 13 | Actress and talk show host whose godmother is actress Sophia Loren: 2 wds. |
| 43% | ELLENDEGENERES | 14 | Talk show host and star of a 1990s ABC sitcom, whose title was her first name: 2 wds. |
| 41% | BIGBROTHER | 10 | CBS reality show hosted by Julie Chen whose first version aired in the Netherlands: 2 wds. |
| 40% | LATENIGHT | 9 | After-hours NBC talk show hosted by Jimmy Fallon (who it's said will replace Jay Leno on "The Tonight Show"): 2 wds. |
| 39% | GEORGELOPEZ | 11 | Talk show host who plays a teacher in "Spare Parts": 2 wds. |
| 39% | RISEANDSHINE | 12 | 43-Across novel about a morning talk show host who is fired because of an on-air gaffe (3 wds.) |
| 39% | ELLENDEGENERES | 14 | Daytime talk show host who is a vegan: 2 wds. |
| 38% | ANDERSONCOOPER | 14 | LGBT host whose show is on CNN: 2 wds. |
| 38% | JIMMYKIMMEL | 11 | Talk show host who recently hosted the Oscars for the second year in a row: 2 wds. |
| 37% | TAVISSMILEY | 11 | PBS talk show host who formerly had a show on NPR: 2 wds. |
| 37% | JIMMYFALLON | 11 | "The Tonight Show" host on the air starting in 2014: 2 wds. |
| 37% | MARIEOSMOND | 11 | Singer and talk show host who has been a spokesperson for Nutrisystem: 2 wds. |
| 37% | JIMMYKIMMEL | 11 | Late-night talk show host who voiced the father in "The Boss Baby": 2 wds. |
| 37% | OPRAHWINFREY | 12 | TV talk show host who received the NAACP's Spingarn Medal in 2000: 2 wds. |
| 36% | KELLYRIPA | 9 | Morning talk show host born in October (2 wds.) |
| 35% | RICKILAKE | 9 | Former talk show host who premiered her documentary "Weed the People" at the SXSW festival in Austin: 2 wds. |
| 35% | STEPHENCOLBERT | 14 | CBS "The Late Show" host whose show was nominated for a 2020 Writers Guild Award for Comedy/Variety Talk Series (2 wds.) |
| 35% | JIMMYKIMMEL | 11 | Late-night talk show host who hosts the prime-time game show "Who Wants to Be a Millionaire": 2 wds. |
| 35% | CAROLBURNETT | 12 | Comedian and variety show host who was awarded the Mark Twain Prize in 2013: 2 wds. |
| 34% | PHILDONAHUE | 11 | Tabloid talk-show host (1967-1996) who wore a skirt during an episode featuring cross-dressers (2 wds.) |
| 34% | DROZ | 4 | Talk show host whose first name is Mehmet |
| 33% | SNOB | 4 | One whose nose is in the air |
| 33% | RIPA | 4 | Talk show host who was once on "All My Children" |
| 33% | CONANOBRIEN | 11 | Redheaded late-night talk show host: 2 wds. |
| 33% | EMMATHOMPSON | 12 | "Love Actually" actress who plays veteran late-night talk show host Katherine Newbury in "Late Night" (2 wds.) |
| 32% | HELLSKITCHEN | 12 | Reality cooking show hosted by 40-Across whose theme song is "Fire" (2 wds.) |
| 32% | DONIMUS | 7 | Morning radio host whose show is simulcast on Fox Business Network: 2 wds. |
| 32% | RICKILAKE | 9 | Former talk show host with a "watery" name: 2 wds. |