| 100% | OPENLINE | 8 | Talk show caller's opportunity (2 wds.) |
| 60% | ROSIEODONNELL | 13 | Talk show host who played one of Murphy Brown's many secretaries: 2 wds. |
| 59% | CHELSEALATELY | 13 | Comedian Handler's talk show on E!: 2 wds. |
| 58% | OPRAHWINFREY | 12 | TV talk show host who received the NAACP's Spingarn Medal in 2000: 2 wds. |
| 57% | THEVIEW | 7 | Talk show recently left by Meghan McCain: 2 wds. |
| 56% | THEVIEW | 7 | Talk show starring Whoopi Goldberg and Joy Behar: 2 wds. |
| 56% | DROZ | 4 | Physician with a syndicated talk show: 2 wds. |
| 56% | CONANOBRIEN | 11 | Redheaded late-night talk show host: 2 wds. |
| 55% | THEVIEW | 7 | TV talk show moderated by Whoopi Goldberg: 2 wds. |
| 55% | DROZ | 4 | Physician with a daily syndicated talk show: 2 wds. |
| 55% | GEORGELOPEZ | 11 | Talk show host who plays a teacher in "Spare Parts": 2 wds. |
| 55% | RICKILAKE | 9 | Former talk show host with a "watery" name: 2 wds. |
| 55% | ELLENDEGENERES | 14 | Daytime talk show host who is a vegan: 2 wds. |
| 54% | DRPHIL | 6 | Daytime talk show host whose surname is McGraw: 2 wds., abbr. |
| 54% | OPENLINE | 8 | Opportunity for a radio talk show caller |
| 52% | JERRYSPRINGER | 13 | TV talk show host with a law degree from Northwestern University: 2 wds. |
| 52% | DREWBARRYMORE | 13 | Actress and talk show host whose godmother is actress Sophia Loren: 2 wds. |
| 52% | HOTONES | 7 | YouTube talk show where celebrities are interviewed while eating spicy wings: 2 wds. |
| 52% | MARIEOSMOND | 11 | Singer and talk show host who has been a spokesperson for Nutrisystem: 2 wds. |
| 52% | DNATEST | 7 | What Maury Povich has a potential father take, for his talk show: 2 wds. |
| 51% | JIMMYKIMMEL | 11 | Talk show host who recently hosted the Oscars for the second year in a row: 2 wds. |
| 51% | JIMMYKIMMEL | 11 | Late-night talk show host who voiced the father in "The Boss Baby": 2 wds. |
| 51% | JIMMYKIMMEL | 11 | ABC talk show host who performed at the 2012 White House Correspondents' Dinner: 2 wds. |
| 51% | CONANOBRIEN | 11 | TBS talk show host who performed at the 2013 White House Correspondents' Dinner: 2 wds. |
| 51% | THEMUPPETS | 10 | ABC series focusing on the fictional talk show "Up Late With Miss Piggy": 2 wds. |
| 51% | BUSYPHILIPPS | 12 | "Cougar Town" actress whose late-night talk show on E! ends this week: 2 wds. |
| 50% | ELLENDEGENERES | 14 | Talk show host and star of a 1990s ABC sitcom, whose title was her first name: 2 wds. |
| 50% | PHILDONAHUE | 11 | Husband of 13-Across who won nine Emmys for hosting his daytime talk show: 2 wds. |
| 49% | THEVIEW | 7 | Talk show featuring Meghan McCain and Whoopi Goldberg (2 wds.) |
| 49% | JOHNNYCARSON | 12 | American talk show host and comedian who hosted "The Tonight Show" for three straight decades: 2 wds. |