| 100% | CONAN | 5 | Talk show hosted by a Harvard grad |
| 58% | CONANOBRIEN | 11 | Longtime talk show host with a degree from Harvard |
| 52% | CHELSEA | 7 | Netflix talk show hosted by comedian Handler |
| 52% | COOKINGWITHGASBAG | 17 | Food Network show hosted by a loudmouth? |
| 52% | FRESH | 5 | "___ Air" (radio talk show hosted by Terry Gross) |
| 50% | REESE | 5 | "Shine On With ___" (DirecTV talk show hosted by actress Witherspoon) |
| 49% | LIGHTS | 6 | "___ Out with David Spade," late-night talk show hosted by David Spade |
| 49% | ARSENIOHALL | 11 | Talk show host who won a season of "Celebrity Apprentice" |
| 48% | DAN | 3 | "The Big Interview With ___ Rather" (AXS show hosted by a former news anchor) |
| 48% | ALI | 3 | "All In with Laila ___" (CBS Saturday morning show hosted by a former boxer) |
| 48% | GEORGELOPEZ | 11 | Talk show host who plays a teacher in "Spare Parts": 2 wds. |
| 47% | ELLENDEGENERES | 14 | Daytime talk show host who is a vegan: 2 wds. |
| 47% | BEATBOBBYFLAY | 13 | Food Network head-to-head cooking show hosted by a former Iron Chef (3 wds.) |
| 47% | OPRAH | 5 | ___ Winfrey, talk show host with an honorary doctorate from Harvard University |
| 46% | CONAN | 5 | ___ O'Brien, talk show host who graduated from Harvard University in 1985 |
| 46% | RICKILAKE | 9 | Former talk show host with a "watery" name: 2 wds. |
| 46% | TAVISSMILEY | 11 | PBS talk show host who formerly had a show on NPR: 2 wds. |
| 46% | SNL | 3 | NBC sketch comedy show hosted by Alec Baldwin a record 17 times (Abbr.) |
| 45% | ALT | 3 | "A Healthy You & Carol ___" (Fox News show hosted by a supermodel) |
| 45% | RONREAGAN | 9 | Host of a short-lived talk show |
| 45% | MARIEOSMOND | 11 | Singer and talk show host who has been a spokesperson for Nutrisystem: 2 wds. |
| 45% | JIMMYKIMMEL | 11 | Talk show host who recently hosted the Oscars for the second year in a row: 2 wds. |
| 44% | DESK | 4 | What a talk show host usually sits behind |
| 44% | RUPAUL | 6 | Host of a self-titled 1990s talk show |
| 44% | JERRYSPRINGER | 13 | TV talk show host with a law degree from Northwestern University: 2 wds. |
| 44% | ELLENDEGENERES | 14 | Talk show host and star of a 1990s ABC sitcom, whose title was her first name: 2 wds. |
| 44% | MASTERCHEF | 10 | Cooking competition show hosted by 40-Across that features a Mystery Box and a Pressure Test |
| 44% | GMA | 3 | A.M. talk show co-hosted by Lara Spencer, Robin Roberts, and George Stephanopoulos, familiarly |
| 42% | THEVOICE | 8 | American reality show hosted by Carson Daly, which works in a format similar to 21-Across: 2 wds. |
| 42% | ROSIETHERIVER | 13 | Waterway named for a talk show host? |