| 100% | SAVEDBYTHEBELL | 14 | Teen sitcom starring 53-Across as A.C. Slater (4 wds.) |
| 51% | ANGIETRIBECA | 12 | TBS sitcom starring 32-Across as a police detective: 2 wds. |
| 51% | UGLYBETTY | 9 | 2000s sitcom starring 35-Across as a magazine assistant: 2 wds. |
| 48% | SUDDENLYSUSAN | 13 | 1996-2000 sitcom starring 15-Across as a magazine writer in San Francisco: 2 wds. |
| 45% | UPALLNIGHT | 10 | NBC sitcom starring 15-/50-Across as a new mom: 3 wds. |
| 43% | THEGOLDENGIRLS | 14 | Sitcom starring 29-Across as Rose Nylund (3 wds.) |
| 43% | HOTINCLEVELAND | 14 | Sitcom starring 29-Across as Elka Ostrovsky (3 wds.) |
| 43% | BIGBANGTHEORY | 13 | CBS sitcom starring Jim Parsons as a brainy Caltech physicist, with "The": 3 wds. |
| 42% | ABOUTABOY | 9 | Current NBC sitcom starring Minnie Driver as a single mom: 3 wds. |
| 41% | APBIO | 5 | Sitcom that starred Glenn Howerton as a high school science teacher: 2 wds. |
| 41% | SCHITTSCREEK | 12 | Emmy-winning sitcom starring 31-Across as Moira Rose (2 wds.) |
| 40% | BECKER | 6 | Sitcom starring Ted Danson as a doctor |
| 40% | CHEERS | 6 | Sitcom starring Ted Danson as a bartender |
| 39% | SAMANTHAWHO | 11 | 2007-2009 ABC sitcom starring Christina Applegate as a recovering amnesiac: 2 wds. |
| 39% | TEDLASSO | 8 | Sitcom starring Jason Sudeikis as a soccer coach |
| 39% | MAJORDAD | 8 | 1989-1993 CBS sitcom starring Gerald McRaney as a military man with stepkids: 2 wds. |
| 39% | TOSIRWITHLOVE | 13 | 1967 drama starring 43-Across as a Guyanese teacher in London (4 wds.) |
| 39% | TOCATCHATHIEF | 13 | 1955 Hitchcock film starring Cary Grant as a retired cat burglar: 4 wds. |
| 38% | EXTENDEDFAMILY | 14 | NBC sitcom starring Jon Cryer as Jim, a man raising kids with his ex-wife Julia: 2 wds. |
| 38% | APBIO | 5 | Sitcom starring Glenn Howerton as a high-school science teacher |
| 38% | MCHALESNAVY | 11 | 1962-1966 sitcom starring Ernest Borgnine as lieutenant commander of a military vessel: 2 wds. |
| 38% | DANINREALLIFE | 13 | 2007 comedy-drama starring Steve Carell as a widowed advice columnist: 4 wds. |
| 37% | ONTV | 4 | Currently playing, as a sitcom: 2 wds. |
| 37% | ALDA | 4 | Star as a sitcom surgeon |
| 37% | HOWIMETYOUR | 11 | With 34-Down, hit sitcom starring 21-Across/4-Down: 4 wds. |
| 37% | VAMPIRESLAYER | 13 | "Buffy the ___," TV series starring Sarah Michelle Gellar as Buffy Summers for which she won a Teen Choice Award: 2 wds. |
| 36% | SAVEDBYTHEBELL | 14 | 1989-1993 teen sitcom rebooted in 2020 for Peacock: 4 wds. |
| 36% | AMEN | 4 | 1980s sitcom starring Sherman Hemsley as a church deacon |
| 36% | AMEN | 4 | Old sitcom starring Sherman Hemsley as a church deacon |
| 36% | ONTV | 4 | Airing or currently playing, as a sitcom: 2 wds. |