| 100% | THEFLINTSTONES | 14 | Television series set in Bedrock that debuted in 1960 as the first animated series to run in prime time (2 wds.) |
| 35% | SOUTHPARK | 9 | Long-running animated series set in the Rockies: 2 wds. |
| 33% | ADVENTURETIME | 13 | Animated Cartoon Network series set in the Land of Ooo: 2 wds. |
| 33% | NANCYDREW | 9 | Fictional amateur detective created as the female counterpart to the series in 13a: 2 wds. |
| 32% | FAMILYGUY | 9 | Seth MacFarlane animated series featuring the voices of 15-Across, 26-Across, and 34-Across that debuted in 1999 (2 wds.) |
| 32% | YOGIBEAR | 8 | "The ___ Show," animated series set in Jellystone Park: 2 wds. |
| 31% | SLADE | 5 | Carter ___, character that debuted in Ghost Rider number 1 as the first to wear the mask |
| 31% | LYNDONJOHNSON | 13 | President whose State of the Union Address was the first to be broadcast live on prime-time television (2 wds.) |
| 31% | BALLDROP | 8 | New Year's Eve celebration in Times Square commonly referred to as the ___: 2 wds. |
| 30% | BECKYHAMMON | 11 | First woman to act as head coach in an NBA game, for the San Antonio Spurs in 2020: 2 wds. |
| 30% | DEADHOUSE | 9 | "Welcome to ___," the first book in the original Goosebumps series by R.L. Stine: 2 wds. |
| 30% | GWENJORGENSEN | 13 | American distance runner and two-time ITU World Champion who was the first to win a triathlon gold for USA in the Olympics: 2 wds. |
| 30% | BARGAINBLOCK | 12 | HGTV show set in Detroit featuring run-down properties that are renovated into starter homes for first-time buyers (2 wds.) |
| 30% | CERTAINGIRLS | 12 | 2008 Jennifer Weiner bestseller that's the sequel to her debut novel "Good in Bed": 2 wds. |
| 30% | ROLEMODEL | 9 | A person that is often looked at as someone to follow in the footsteps of : 2 wds. |
| 30% | ABRAHAMLINCOLN | 14 | President who signed the Yosemite Valley Grant Act in 1864, setting aside land for preservation for the first time: 2 wds. |
| 30% | CHUCKBERRY | 10 | His 1958 song "Run Rudolph Run" hit the top 10 for the first time ever in 2021: 2 wds. |
| 30% | TEXASRANGERS | 12 | AL West team that won the franchise's first-ever World Series in 2023, after 62 years: 2 wds. |
| 29% | SOUTHPARK | 9 | Animated Comedy Central series set in a small town in Colorado: 2 wds. |
| 29% | GREYSANATOMY | 12 | ABC's medical drama TV series starring Ellen Pompeo that is set in the fictional Seattle Grace Hospital: 2 wds. |
| 29% | FAMILYGUY | 9 | Animated Fox series set in Quahog, Rhode Island: 2 wds. |
| 29% | SKINS | 5 | E4 television teen drama series set in Bristol that ran from 2007-13 |
| 29% | JOHNNYMANZIEL | 13 | First freshman to win the 15-Across, in 2012: 2 wds. |
| 29% | THEGOLDBERGS | 12 | ABC comedy series set in the 1980s: 2 wds. |
| 29% | STRANGERTHINGS | 14 | Netflix horror series set in the 1980s: 2 wds. |
| 29% | THEAMERICANS | 12 | FX spy series set in the 1980s: 2 wds. |
| 29% | LITTLEBIGHORN | 13 | Iconic site in Montana, that preserves the site of the battle that was fought here, commonly referred to as "Custer's Last Stand": 2 wds. |
| 29% | WAYNEGRETZKY | 12 | Hockey legend who was the first since Bobby Orr to tally 100+ assists in a season, and did so 11 times: 2 wds. |
| 28% | DOCTORWHO | 9 | BBC sci-fi series that debuted in 1963: 2 wds. |
| 28% | THEXFILES | 9 | Paranormal TV series featuring the characters 15-Across, 21-Across, and 41-Across that debuted in 1993 (2 wds.) |