| 100% | IRENE | 5 | The "she" in the line "To Sherlock Holmes she is always THE woman" |
| 50% | ADLER | 5 | Irene who was the only woman to outwit Sherlock Holmes |
| 49% | SARAHPALIN | 10 | In 2006, she became the first woman to be elected governor of Alaska: 2 wds. |
| 49% | SUSANAMARTINEZ | 14 | In 2010, she became the first woman to be elected governor of New Mexico: 2 wds. |
| 49% | NIKKIHALEY | 10 | In 2010, she became the first woman to be elected governor of South Carolina: 2 wds. |
| 45% | WOOLF | 5 | Writer of the line “A woman must have money and a room of her own if she is to write fiction” |
| 45% | NEWLOOK | 7 | Name by which the women's fashion lines Corolle and Huit, introduced in 1947 by Christian Dior, came to be known |
| 44% | SALLYRIDE | 9 | She was the first American woman in Space |
| 43% | THATSMYQUEUE | 12 | "Oh, I'm supposed to be in the line over there"? |
| 43% | ASPS | 4 | The snakes in the movie line "Snakes. Why'd it have to be snakes?" |
| 43% | NEXT | 4 | "The eldest son is ___ in line to the throne." |
| 43% | OBERLIN | 7 | Ohio college that was the first in the U.S. to admit women |
| 42% | HAPPILYEVERAFT | 14 | Always glad to be seated in the back of the boat? |
| 42% | HEIR | 4 | ___ to the throne (next in line to be king, perhaps) |
| 42% | SOFIA | 5 | Princess ___, young royal who is in the line of succession to the Spanish throne |
| 42% | OSCAR | 5 | Prince ___, young royal who is in the line of succession to the Swedish throne |
| 42% | COCAINE | 7 | The solution referred to in Sherlock Holmes's "seven-per-cent solution" |
| 42% | BRIDAL | 6 | Referring to a woman in the context of her wedding |
| 42% | IRENE | 5 | "The woman," to Sherlock Holmes |
| 42% | OBERLIN | 7 | Ohio college that was the first in the U.S. to award degrees to women |
| 42% | LIAM | 4 | Prince ___, young royal who is in the line of succession to the throne of Luxembourg |
| 41% | PREGNANT | 8 | What a woman is when she has "a bun in the oven" |
| 41% | DIANA | 5 | Elton John's "Candle in the Wind" was rewritten to honor her |
| 41% | JENNY | 5 | Woman in a 1982 hit who can be reached using the starts of the answers to the starred clues |
| 41% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 41% | ADLER | 5 | Irene ___ ("the Woman," to Sherlock Holmes) |
| 41% | JESMYNWARD | 10 | In 2017, she became the first woman to win two National Book Awards for fiction |
| 40% | ROSA | 4 | Parks who was the first woman to lie in honor in the Capitol |
| 40% | LEE | 3 | Rebecca ___ Crumpler, physician who was the first African-American woman in the US to earn a medical degree |
| 40% | BASILRATHBONE | 13 | Sherlock Holmes in "The Woman in Green" |