| 100% | SMITHS | 6 | The ___, "American Dad!" family helmed by Stan and Francine, featuring their children Hayley and Steve |
| 64% | MARSHES | 7 | The ___, "South Park" family helmed by Randy and Sharon, featuring their children Stan and Shelley |
| 56% | GRIFFINS | 8 | The ___, "Family Guy" family helmed by Peter and Lois, featuring their children Meg, Chris, and Stewie |
| 55% | PICKLES | 7 | The ___, family from the namesake show helmed by Stu and Didi, featuring their children Dil and Tommy |
| 55% | JETSONS | 7 | The ___, family from the namesake show helmed by George and Jane, featuring their children Judy and Elroy |
| 35% | MRPIBB | 6 | Stan and Francine's preferred drink on American Dad |
| 32% | BLONDIE | 7 | Comic strip featuring the Bumsteads and their children, Alexander and Cookie |
| 32% | THUNDERBIRDS | 12 | 1960s ITV puppet series featuring the Tracy family devised by Sylvia and Gerry Anderson |
| 32% | THEFAMOUSFIVE | 13 | Series of children's novels written by Enid Blyton featuring the adventures of a group of young children and their dog Timmy: 3 wds. |
| 31% | BABYBLUES | 9 | Comic strip featuring the MacPhersons and their children, Zoe, Hammie, and Wren (2 wds.) |
| 30% | HIANDLOIS | 9 | Comic strip featuring the Flagstons and their children, Chip, Dot, Ditto, and Trixie (3 wds.) |
| 29% | GOOGLE | 6 | American tech giant made popular by their search engine, and is one of the world's biggest brands |
| 29% | DEARTHEODOSIA | 13 | “Hamilton” duet sung by Burr and Hamilton to their children |
| 28% | THEBORROWERS | 12 | & 15A 1959 children’s book by Mary Norton; third in a series featuring the Clock family |
| 28% | GUYSWITHKIDS | 12 | A TV series co-created and written by Jimmy Fallon, chronicling the lives of three friends and their children: 3 wds. |
| 28% | BINDI | 5 | "___ the Jungle Girl," nature documentary series presented by Steve and Terri Irwin's daughter starring the Irwin family |
| 28% | CAMPTIGER | 9 | Children's book by 52-Across and illustrator John Rocco that features a big cat in the woods (2 wds.) |
| 28% | LONESOME | 8 | "Blue & ___," 25th American studio album by The Rolling Stones and the first one to feature only cover songs |
| 27% | ADDAMS | 6 | Last name of the TV family headed by Morticia and Gomez |
| 27% | STANSMITH | 9 | Head of the family in American Dad |
| 26% | ARROW | 5 | Feature shared by the emojis 💘 and 🏹 |
| 25% | IDO | 3 | Words exchanged by the bride and groom on their wedding day |
| 25% | ASTAR | 5 | "Everybody is ___," song by Sly and the Family Stone: 2 wds. |
| 25% | STATIONWAGON | 12 | Family car largely replaced by the minivan and SUV |
| 25% | PETERGRIFFIN | 12 | The main character and father of the family in the American sitcom, "Family Guy": 2 wds. |
| 25% | RATS | 4 | "Mrs. Frisby and the ___ of NIMH" (children's classic by Robert C. O'Brien featuring rodents) |
| 25% | FOXTROT | 7 | Comic strip featuring Andy and Roger, and their children, Peter, Paige and Jason |
| 25% | FACIALEXPRESSION | 16 | Many an emoji, and a feature of the starred clues and their answers? |