| 100% | ALGEBRAIST | 10 | The —, 2004 novel by Iain M Banks set in the year 4034 |
| 42% | CROWROAD | 8 | The —, 1992 novel by Iain Banks |
| 42% | BRIDGE | 6 | The —, 1986 novel by Iain Banks |
| 42% | BRAVENEWWORLD | 13 | *Dystopian novel set in the year 2540 |
| 42% | FAIREST | 7 | 2006 novel by Gail Carson Levin set in the kingdom of Ayortha |
| 41% | HAMMER | 6 | "The ___ of God," 1993 sci-fi novel by Arthur C. Clarke that is set in the year 2109 |
| 41% | FACTORY | 7 | The Wasp __, debut dystopian novel by Iain Banks |
| 40% | NARNIA | 6 | Setting of seven fantasy novels by C S Lewis published in the 1950s |
| 38% | DARK | 4 | "After ___," 2004 novel by Haruki Murakami which is set in Tokyo |
| 37% | MANOFWAR | 8 | 2003 novel by Alexander Kent set in the West Indies |
| 36% | JAZZ | 4 | Historical novel by Toni Morrison set in Harlem in the 1920s |
| 36% | GOLDEN | 6 | "The ___ Compass," fantasy novel by Philip Pullman that is set in the Arctic |
| 36% | ONEBYONE | 8 | Mystery novel by 45-Across set in the French Alps (3 wds.) |
| 36% | MONEYPENNY | 10 | Miss —, secretary to M in the James Bond novels by Ian Fleming |
| 35% | THEFOURWINDS | 12 | Novel by 29-Across set in the Great Plains during the Dust Bowl era (3 wds.) |
| 35% | THEADDRESS | 10 | Novel by 39-Across set in New York City's apartment building The Dakota (2 wds.) |
| 35% | SEA | 3 | "The Winter ___," 2008 novel by Susanna Kearsley set in the Slains Castle at Cruden Bay |
| 35% | THEGREATALONE | 13 | 2018 novel by 44-Across set in Alaska after the Vietnam War (3 wds.) |
| 35% | RAMA | 4 | "Rendezvous with ___," 1973 novel by Arthur C. Clarke that is set in the 2130s |
| 35% | PUDDNHEAD | 9 | & 21A 1894 novel by Mark Twain set in the town of Dawson's Landing |
| 35% | TOLLS | 5 | "For Whom the Bell ___," novel by Ernest Hemingway, set in the Spanish Civil War and is regarded as one of his best works |
| 35% | RYE | 3 | "The Catcher in the ___," novel by J.D. Salinger that is set in New York City |
| 35% | SASHA | 5 | ___ Banks, American professional wrestler who was named Wrestler of the Year by Sports Illustrated in 2020 |
| 35% | VESUVIUSCLUB | 12 | The —, 2004 novel by Mark Gatiss |
| 35% | ENEMY | 5 | The —, 2004 novel by Lee Child |
| 35% | WRATH | 5 | "The Grapes of ___," novel by John Steinbeck, set in the Great Depression, that was a major reason for him winning the Nobel Prize |
| 34% | CHOLERA | 7 | Novel by García Márquez: Love in the Time of __ |
| 34% | ICLAUDIUS | 9 | Novel with the line "My birth occurred in the 744th year after the foundation of Rome by Romulus" |