| 100% | FORTYTWO | 8 | The answer to "Life, the Universe and Everything," per Douglas Adams |
| 60% | FORTYTWO | 8 | Number that’s the answer to the Ultimate Question of Life, the Universe and Everything, in “The Hitchhiker’s Guide to the Galaxy” |
| 53% | ALL | 3 | Life, the universe, and everything |
| 44% | SCIENCE | 7 | "The great antidote to the poison of enthusiasm and superstition," per Adam Smith |
| 40% | STRINGENSEMBLES | 15 | Chamber groups ... and the answers to starred clues? |
| 39% | PALS | 4 | Friends that surround the answers to 21-, 26-, 43- and 50-Across |
| 39% | UPPERCASE | 9 | Caps, and a hint to the answers to starred clues |
| 39% | THREELINES | 10 | Feature of haiku, and of the answers to starred clues |
| 39% | FLIPSIDES | 9 | Opposites, and what the answers to starred clues literally contain |
| 39% | BOTTOMLINE | 10 | Net profit, and what the answers to starred clues have |
| 39% | NORTHERNLIGHTS | 14 | Arctic spectacle ... and what the answers to starred clues have? |
| 39% | MIDDLEGROUND | 12 | Compromising standpoint ... and what the answers to starred clues contain? |
| 39% | THINKQUICKLY | 12 | To understand this puzzle's theme, read the ends of the answers to the starred clues and ... |
| 39% | ALCOHOL | 7 | "The cause of, and solution to, all of life's problems," per Homer Simpson |
| 38% | ELF | 3 | Christmas figure seen in the answers to 18, 29, 46, and 60 Across |
| 38% | NATURALLAW | 10 | Basis for the rights to life and liberty, to John Locke |
| 38% | TURNOFPHRASE | 12 | "Nice" expression ... and a hint to the answers to starred clues |
| 38% | STUCKINARUT | 11 | Trapped by mundanity ... and hint to the answers to starred clues |
| 38% | STOPIN | 6 | Visit briefly ... and a hint to the answers to starred clues |
| 38% | LASTLAUGH | 9 | Ultimate satisfaction, and a hint to the answers to starred clues |
| 38% | BELLBOTTOMS | 11 | Retro pants, and a hint to the answers to starred clues |
| 38% | CANNEDHAMS | 10 | Spam relatives ... and a hint to the answers to starred clues |
| 38% | OPENINGACT | 10 | Show starter ... and a hint to the answers to starred clues |
| 38% | DOUBLEDOWN | 10 | Blackjack bet ... and a hint to the answers to starred clues |
| 38% | MIXEDDOUBLES | 12 | Wimbledon category, and a hint to the answers to starred clues |
| 38% | SECONDLOOK | 10 | Reappraisal, and what the answers to the starred clues all have? |
| 38% | PAIROFPANTS | 11 | Trousers, and what the answer to each starred clue literally is |
| 38% | CREATUREFEATURE | 15 | Monster movie, and what the answer to each starred clue has? |
| 38% | TIGHTENDS | 9 | Some football linemen ... and what the answers to starred clues have? |
| 38% | DOUBLEDATES | 11 | Two-couple outings ... and what the answers to starred clues are? |