| 100% | THEORY | 6 | The Big Bang __; Sheldon Cooper's sitcom |
| 69% | BAZINGA | 7 | Sheldon Cooper's catchphrase in "The Big Bang Theory" |
| 69% | BAZINGA | 7 | Sheldon Cooper's catchphrase on "The Big Bang Theory" |
| 61% | YOUNG | 5 | "___ Sheldon," sitcom set in the 1990s based on Sheldon Cooper from "The Big Bang Theory" |
| 61% | MARY | 4 | ___ Cooper, Sheldon Cooper's mother in "The Big Bang Theory" |
| 60% | CRAZY | 5 | "I'm not ___ my mother had me tested," Sheldon Cooper's common retort in "The Big Bang Theory" |
| 59% | NERD | 4 | Sheldon Cooper of the "Big Bang Theory", for example |
| 55% | JIM | 3 | ___ Parsons, multiple Emmy-winning openly gay actor of "The Big Bang Theory" who portrayed Sheldon Cooper |
| 54% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 51% | AMY | 3 | Sheldon Cooper and ___ Farrah Fowler, popular fictional couple from "The Big Bang Theory" |
| 51% | THEORY | 6 | "The Big Bang ___," popular sitcom |
| 50% | YOUNG | 5 | "The Big Bang Theory" spinoff "___ Sheldon" |
| 50% | YOUNG | 5 | "The Big Bang Theory" prequel series "___ Sheldon" |
| 50% | CHESS | 5 | "Three-Person ___," strategy game developed by Sheldon Cooper in "The Big Bang Theory" |
| 48% | RAJ | 3 | "The Big Bang Theory" chum of Sheldon and Leonard |
| 48% | LAURIEMETCALF | 13 | "The Big Bang Theory" actress whose daughter portrays her character's younger self on "Young Sheldon": 2 wds. |
| 48% | JONES | 5 | "Indiana ___: Raiders of the Lost Ark", one of Sheldon Cooper's favorite movies in "The Big Bang Theory" |
| 48% | LORRE | 5 | "The Big Bang Theory" and "Young Sheldon" co-creator Chuck |
| 48% | RAJ | 3 | "The Big Bang Theory" pal of Sheldon, Leonard, and Howard |
| 47% | AMY | 3 | Sheldon's girlfriend on "The Big Bang Theory" |
| 47% | LEONARD | 7 | Sheldon's buddy on "The Big Bang Theory" |
| 47% | AMY | 3 | Sheldon's girlfriend in "The Big Bang Theory" |
| 47% | AMY | 3 | Sheldon's wife on "The Big Bang Theory" |
| 47% | CHUCKLORRE | 10 | Creator of "Two and a Half Men" and "The Big Bang Theory," who is also the co-creator of CBS's new show "Young Sheldon": 2 wds. |
| 47% | BAZINGA | 7 | The Big Bang Theory catchword |
| 47% | NERD | 4 | The Big Bang Theory stereotype |
| 47% | BAZINGA | 7 | Sheldon word for "gotcha" in The Big Bang Theory |
| 46% | BEGINNINGOFTIME | 15 | The Big Bang, to a physicist |
| 46% | MAYIM | 5 | The Big Bang Theory actress Bialik |
| 46% | PARSONS | 7 | Jim who plays Sheldon on The Big Bang Theory |