| 100% | GUNTHER | 7 | The famous barista in Central Perk who speaks Dutch and English, played by James Michael Tyler in "Friends" |
| 35% | SETH | 4 | ___ and Evan, friends from the film "Superbad" who are played by Jonah Hill and Michael Cera |
| 34% | GWYNN | 5 | Michael —, English actor who played Hermes in 1963 adventure film Jason and the Argonauts |
| 32% | ETTA | 4 | James who was played by Beyoncé in the biopic "Cadillac Records" |
| 32% | GUNTHER | 7 | Central Perk's barista who loved Rachel in Friends |
| 31% | WET | 3 | The ___ Bandits, villains in "Home Alone" who are played by Joe Pesci and Daniel Stern |
| 30% | SAM | 3 | ___ Wilson, Captain America's friend and sidekick played by Anthony Mackie in the Marvel Cinematic Universe |
| 30% | ATKINSON | 8 | Rowan —, comic actor who played the title role in films Bean and Johnny English |
| 29% | ALEX | 4 | ___ Cross, fictional former FBI agent and psychologist created by James Patterson who is the protagonist in many of his books |
| 29% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 29% | GOOSE | 5 | Maverick and ___, friends from the film "Top Gun" who are played by Tom Cruise and Anthony Edwards |
| 29% | EVANS | 5 | Barry —, actor who played Michael Upton in ITV sitcoms Doctor at Large and Doctor in the House |
| 29% | TEDDANSON | 9 | "Cheers" and "CSI: Cyber" actor who plays Michael, the "afterlife architect" in 15a: 2 wds. |
| 29% | GEORGECOSTANZA | 14 | Character who is Jerry's best friend since high school and is played by Jason Alexander on the show "Seinfeld": 2 wds. |
| 28% | HAN | 3 | ___ Solo and Chewbacca, friends from the "Star Wars" franchise who are played by Harrison Ford and Peter Mayhew |
| 28% | TED | 3 | Bill and ___, friends from the eponymous trilogy of films who are played by Alex Winter and Keanu Reeves |
| 28% | ANTONCHEKHOV | 12 | Russian writer who created the characters played by 15-Across, 40-Across, and 45-Across in "The Seagull" |
| 28% | RALPH | 5 | ___ Fiennes, English actor who played the role of Gareth Mallory in James Bond movies |
| 28% | DENCH | 5 | Judi ___, English actress who played the role of M in numerous James Bond movies |
| 28% | GREEN | 5 | Mr. ___, character from the classic board game "Clue" who is played by Michael McKean in the eponymous 1985 film |
| 28% | LOISMAXWELL | 11 | Actress who played Miss Moneypenny in 1962 action film Dr No and thirteen others of the James Bond series |
| 28% | DWIGHTSCHRUTE | 13 | A character from "The Office" played by Rainn Wilson, who is the nemesis and eventual friend of 42a: 2 wds |
| 28% | WILLIAMSHATNER | 14 | Actor who first played James T. Kirk, the captain played by Chris Pine in the new "Star Trek" films (2 wds.) |
| 27% | DAVE | 4 | ___ Coulier, who played Joey Gladstone, Jesse and Danny's best friend in the 1987 sitcom "Full House" |
| 27% | COSMOKRAMER | 11 | Character played by Michael Richards in "Seinfeld", who is 32-Across's neighbor and is often called a "hipster doofus": 2 wds. |
| 27% | COSMO | 5 | James ___, who played Father Christmas in the fantasy film "The Chronicles of Narnia: The Lion, the Witch and the Wardrobe" |
| 27% | MARK | 4 | ___ Twain, famous author who was friends with the scientist Nikola Tesla and often spent time in his lab |
| 27% | GARYSINISE | 10 | Actor who played Mac Taylor on "CSI: NY" and was awarded the James Cardinal Gibbons Medal in 2017 |
| 27% | ULTRON | 6 | Supervillain played by James Spader in the second Avengers movie |
| 27% | NAOMIEHARRIS | 12 | "Moonlight" actress who plays Eve Moneypenny in the 2012 and 2015 James Bond films "Skyfall" and "Spectre" (2 wds.) |