| 100% | HOPON | 5 | The first "HO" of a tourist's HOHO bus: 2 wds. |
| 51% | MAEJEMISON | 10 | The first Black female astronaut and winner of a National Achievement Scholarship in 1973: 2 wds. |
| 48% | NANCYREAGAN | 11 | First Lady of the United States (1981-1989) who wrote "To Love a Child": 2 wds. |
| 48% | ANNPRESTON | 10 | American physician and activist who was the first female dean of a medical school in the world: 2 wds. |
| 46% | ACTI | 4 | First part of a play: 2 wds. |
| 45% | BARBARABUSH | 11 | First Lady of the United States (1989-1993) who wrote "Millie's Book": 2 wds. |
| 44% | LABORDAY | 8 | It's celebrated during the first week of September: 2 wds. |
| 44% | REARTIRE | 8 | What's on the back wheel of a bike: 2 wds. |
| 44% | EVELYNASHFORD | 13 | The first track and field athlete to run 100 meters under 11 seconds in an Olympic Games and who has won a total of 5 Olympic medals: 2 wds. |
| 44% | FATLIP | 6 | Result of a punch to the mouth: 2 wds. |
| 44% | DEARSANTA | 9 | Start of a letter to the North Pole: 2 wds. |
| 44% | FROGSPAWN | 9 | The first stage of a tadpole's life cycle |
| 43% | TIGERWOODS | 10 | First winner of the PGA's FedEx Cup (2007) (2 wds.) |
| 43% | SHERYLSWOOPES | 13 | She was the first player signed by a WNBA team: 2 wds. |
| 43% | TAYLORSWIFT | 11 | Multiple Grammy-winning singer-songwriter who is the first-ever recipient of Billboard's Woman of the Decade Award: 2 wds. |
| 42% | PITABREAD | 9 | The wrapping of a falafel sandwich: 2 wds. |
| 42% | JOHNCARPENTER | 13 | Director of the first "Halloween": 2 wds. |
| 42% | ACTI | 4 | First part of a musical (2 wds.) |
| 42% | ACTI | 4 | First part of a play (2 wds.) |
| 42% | MARIECURIE | 10 | Scientist who was the first female professor at the University of Paris: 2 wds. |
| 42% | NEWYORK | 7 | Northeastern state that's the first part of two NFL teams' names: 2 wds. |
| 42% | LORNASIMPSON | 12 | "Projects 23" photographer who was the first African-American woman to have a solo exhibition at the Museum of Modern Art (2 wds.) |
| 41% | NOWI | 4 | The start of a prayer, "___ lay me down...": 2 wds. |
| 41% | ACTI | 4 | First part of a stage play (2 wds.) |
| 41% | USEIT | 5 | First part of a fitness motto (2 wds.) |
| 41% | ZOESALDANA | 10 | "Avatar" actress who played a pirate in the first "Pirates of the Caribbean" film: 2 wds. |
| 41% | NANCYPELOSI | 11 | Democratic congresswoman from California who was the first female Speaker of the House: 2 wds. |
| 41% | SARAHPALIN | 10 | In 2006, she became the first woman to be elected governor of Alaska: 2 wds. |
| 41% | MICHELLEOBAMA | 13 | First Lady of the United States (2009-2017) who wrote "Becoming": 2 wds. |
| 41% | SHIALABEOUF | 11 | Star of the first three "Transformers" movies: 2 wds. |