| 100% | ELDORADO | 8 | The first complete navigation of the Amazon was in search of this |
| 54% | ARES | 4 | The Amazons were the daughter of this god, in myth |
| 54% | OLYMPIC | 7 | The first modern one of these games was in Greece |
| 49% | ORELLANA | 8 | Francisco de —, 16th-century Spanish explorer who completed the first known navigation of the entire length of the Amazon River |
| 49% | PERU | 4 | Most distant source of the Amazon is located on the Cordillera Rumi Cruz in this country |
| 48% | JET | 3 | The Lippisch Ente was the first one of these to fly, in 1928 |
| 47% | VCR | 3 | The first commercial one of these was introduced by Ampex in 1956 and cost roughly $50,000 |
| 47% | ATOMICPILE | 10 | The first one of these was built by Fermi and his team in 1942 |
| 46% | GOREVIDALNOVELS | 15 | What the first words of eight long answers in this puzzle are |
| 46% | JOHNGRISHAMNOVEL | 16 | What the first word of each of seven answers in this puzzle is, when preceded by “The” |
| 46% | ICHIRO | 6 | Suzuki who will be the first Japanese player in the Baseball Hall of Fame when inducted this July |
| 45% | SLANT | 5 | Incline (and a hint to the location in this completed puzzle of the first line of 9- & 59-Across) |
| 45% | KENTUCKYDERBY | 13 | First leg of the Triple Crown, whose levels of success can be found in this puzzle's circled letters |
| 45% | USN | 3 | JFK was the first president to have served in this branch of the US Armed Forces |
| 45% | DOG | 3 | President Trump is the first president in over 100 years not to have one of these |
| 44% | PARROT | 6 | The orange-winged amazon is a type of this bird |
| 44% | POETRY | 6 | "April is National ___ Month! Complete the rhyme hidden in this crossword and celebrate the beauty of verse!" |
| 44% | ATM | 3 | Installation of October 1997 in Canada's capital was the world's first talking one of these |
| 44% | TARA | 4 | Author Westover whose memoir is spelled out in the first letters of this puzzle's eight circled schools |
| 43% | CAPTAIN | 7 | This person is in command of the ship |
| 43% | MEL | 3 | Allen who was the first host of "This Week in Baseball" |
| 42% | HALF | 4 | First ___ (only portion of the alphabet used in this puzzle's grid) |
| 42% | SNOW | 4 | "It's the first ___ of the year! The holiday season is upon us! Look out for fun hidden themes throughout this month in DTC!" |
| 42% | FAE | 3 | Baby who was the first infant subject of a xenotransplant procedure in 1984 |
| 42% | ILHAN | 5 | First name of the This Is What America Looks Like memoirist |
| 42% | PROGRESS | 8 | The first step in this is discontent |
| 42% | AGE | 3 | Donald Trump was indeed the greatest president in terms of this on Inauguration Day |
| 41% | PIZZA | 5 | The "Hawaiian" version of this food was invented in Canada |
| 41% | JAMESJOYCE | 10 | The first part of his ''Ulysses'' was published in 1918 |
| 41% | CANADA | 6 | Most of the world's lakes are in this country |