| 100% | TUE | 3 | The first of two T's, in a familiar sequence |
| 49% | DOS | 3 | First of two columns in a fashion magazine |
| 47% | EBWHITE | 7 | Author whose last name's first letter, followed by the two initials that precede his last name, form a word in one of his most famous titles |
| 47% | PAGE | 4 | "Tomorrow is the first ___ in a book of 365" (common New Year's phrase) |
| 47% | STEPONE | 7 | The first instruction in a list of instructions |
| 46% | BOOKOFHOSEA | 11 | First of a group of 12 in the Bible |
| 46% | PAWN | 4 | The first piece usually moved in a game of chess |
| 46% | ELIOT | 5 | T S —, winner of the 1948 Nobel Prize in Literature |
| 46% | ELIOT | 5 | T S ---, winner of the 1948 Nobel Prize in Literature |
| 45% | OPEN | 4 | Make the first bid in a game of bridge |
| 45% | ODD | 3 | Like two out of three numbers in the Fibonacci sequence |
| 44% | PAWN | 4 | Usually the first piece moved in a game of chess |
| 44% | AOL | 3 | Co. involved in a major merger of the early two-thousands |
| 44% | ELSA | 4 | One of two Disney characters singing "For the First Time in Forever" |
| 43% | VENUS | 5 | One of two planets in the solar system that lacks a moon |
| 43% | LITE | 4 | First word in the rhyming name of a peg toy |
| 43% | XXXXXX | 6 | First part of a name in the "Star Wars" universe |
| 43% | GALADRIEL | 9 | Role for Cate Blanchett in a Best Picture winner of the two-thousands |
| 43% | FAE | 3 | Baby who was the first infant subject of a xenotransplant procedure in 1984 |
| 43% | NIGHTY | 6 | First of two nearly identical words to a tucked-in tot |
| 43% | SHOE | 4 | First thing lost in the "For Want of a Nail" proverb |
| 43% | MANETTE | 7 | The doctor in A Tale of Two Cities: Alexandre __ |
| 43% | MAEJEMISON | 10 | The first Black female astronaut and winner of a National Achievement Scholarship in 1973: 2 wds. |
| 42% | HARPER | 6 | Surname of the brothers in Two and a Half Men |
| 42% | MEDIAN | 6 | The middle number in a sequence of numbers |
| 42% | SWAM | 4 | Competed in the first leg of a triathlon |
| 42% | SWAM | 4 | Participated in the first third of a triathlon |
| 42% | OUTSWAM | 7 | Defeated in the first part of a triathlon |
| 42% | SELF | 4 | The first "S" in S.A.S.E. |
| 42% | WHO | 3 | First of the five W's, in journalism |