| 100% | SOJOURNER | 9 | The first wheeled vehicle to rove on Mars |
| 42% | JOBONE | 6 | The first task on the to-do list |
| 42% | ONEPIN | 6 | The first to go on a strike, usually |
| 40% | ARMSTRONG | 9 | Neil, the first person to walk on the moon |
| 40% | ARMSTRONG | 9 | Neil, the first person to step on the moon |
| 39% | INC | 3 | The first magazine to feature Steve Jobs on its cover, in 1981 |
| 39% | TASS | 4 | News agency that was the first to report on Sputnik |
| 39% | INDIA | 5 | First country to discover water on the moon |
| 39% | LINEONE | 7 | What the first call to a receptionist might come in on |
| 39% | USA | 3 | First nation to put a man on the moon |
| 39% | APRIL | 5 | Month in 2021 when NASA's Ingenuity became the first powered aircraft to fly on Mars |
| 38% | ITSME | 5 | First line on the phone to someone you know well |
| 38% | CLAY | 4 | Something to throw on the wheel |
| 38% | PGA | 3 | Babe Zaharias was the first woman to compete on its tour, in brief |
| 38% | NWA | 3 | Group that had the first hardcore rap album to reach #1 on Billboard |
| 37% | NAOMAMPBELL | 11 | First Black model to appear on the cover of French Vogue |
| 37% | STEERING | 8 | Place hands on this wheel to direct a vehicle |
| 37% | LUNA | 4 | ___ 9, first spacecraft to land softly on the moon |
| 37% | JAWS | 4 | First major film to be shot on the ocean |
| 37% | ARMSTRONG | 9 | First person to walk on the moon |
| 37% | OCEAN | 5 | Home to the first animals on Earth |
| 37% | EBERT | 5 | The first film critic to receive a star on the Hollywood Walk of Fame |
| 37% | OMAR | 4 | Ilhan who was the first person to wear a hijab on the House floor |
| 37% | ESA | 3 | Intl. org. that was the first to land a probe on a comet (2014) |
| 37% | ICET | 4 | One of the first musicians to have an "explicit content" sticker on an album |
| 37% | SEANCONNERY | 11 | First actor to play James Bond on the big screen (2 wds.) |
| 37% | ALYN | 4 | Kirk ___, first actor to play Superman on the big screen |
| 37% | INC | 3 | First national magazine to feature Steve Jobs on the cover |
| 37% | YEA | 3 | One on the first side to vote, usually |
| 37% | NEIL | 4 | First person to walk on the moon, Armstrong |