| 100% | ALCOHOL | 7 | The intoxicating component of beer and spirits |
| 42% | REALALE | 7 | Beer stored in barrels and pumped without the use of carbon dioxide |
| 41% | ZAC | 3 | Efron of The Greatest Showman and The Greatest Beer Run Ever |
| 41% | GOING | 5 | With 39- and 42-Across, activity of the spirits in this puzzle |
| 40% | MOVINGPARTS | 11 | Working components of an engine ... or what the ends of 18-, 23-, 34- and 47-Across are? |
| 39% | FOAMS | 5 | Features of beer and sponges |
| 39% | HAZLITT | 7 | William —, English essayist and critic; author of 1825 collection The Spirit of the Age |
| 39% | GUINNESS | 8 | Maker of beer and record books |
| 39% | ESTROGEN | 8 | Component of the pill |
| 38% | TIN | 3 | Component of pewter and solder |
| 38% | SMALLA | 6 | Component of the "at" sign |
| 38% | HEATINGELEMENTS | 15 | Components of radiators and toasters |
| 38% | MTS | 3 | Components of the Rockies: Abbr. |
| 38% | OPERAS | 6 | Components of the “Ring” cycle |
| 37% | ACRYLIC | 7 | Component of some paint and nails |
| 37% | LDOPA | 5 | Component of the combo drug Sinemet |
| 37% | ANIL | 4 | Component of the pigment Maya blue |
| 37% | REEDS | 5 | Components of accordions, bagpipes, and clarinets |
| 37% | ELEMENT | 7 | With 62-Across, a key component of any good prank, and a hint to the beginnings of the prankster's tools herein |
| 37% | PROHIBITION | 11 | Period from 1920-33 in the US when the manufacture, transportation and sale of intoxicating liquor was banned |
| 37% | LOCUST | 6 | Component of the eighth plague of Egypt |
| 37% | DISK | 4 | Component of the Tower of Hanoi puzzle |
| 37% | KITCHENZINC | 11 | Component of brass drawer pulls and faucets? |
| 37% | STAR | 4 | Component of the Big Dipper, for example |
| 37% | SUMAC | 5 | Component of the spice blend za'atar |
| 37% | LANDERS | 7 | Components of Mars's Viking and Pathfinder |
| 36% | IRIS | 4 | Colored component of the eye |
| 36% | CELLULOSE | 9 | The main component of the plant cell wall |
| 36% | REDROCK | 7 | Component of many sandstone features in the Southwest |
| 36% | CEE | 3 | Major component of the euro symbol |