| 100% | CLARKKENT | 9 | The lead character in "Smallville" who eventually becomes Superman, played by Tom Welling: 2 wds. |
| 45% | JERRYSEINFELD | 13 | The lead character from "Seinfeld", who is a semi-fictional version of the actor who plays the role and goes by the same name: 2 wds. |
| 45% | MELGIBSON | 9 | Actor who played the lead character, "Mad" Max Rockatansky in the 1979 film "Mad Max": 2 wds. |
| 44% | BRADBELLICK | 11 | Character played by Wade Williams who is introduced as the captain of Fox River's correctional officers in "Prison Break": 2 wds. |
| 42% | ANTHONYRAMOS | 12 | "A Star Is Born" actor who plays Usnavi, the lead character in 18-Across: 2 wds. |
| 42% | PIPERCHAPMAN | 12 | Lead character played by Taylor Schilling on "Orange Is the New Black": 2 wds. |
| 42% | ALFIESOLOMONS | 13 | "Peaky Blinders" character, played by Tom Hardy, who ran a distillery and was seen on the show from season 2 till 4: 2 wds. |
| 41% | JIMHALPERT | 10 | A character from "The Office" played by John Krasinski, who eventually marries the receptionist Pam: 2 wds |
| 41% | MIKEWHEELER | 11 | Played by Finn Wolfhard, character who is one of Will Byers' three friends in "Stranger Things": 2 wds. |
| 40% | STARRCARTER | 11 | Character played by Amandla Stenberg in the movie adaptation of 30-Across: 2 wds. |
| 40% | HEATHERLEE | 10 | Character played by Alicia Vikander in the action spy movie "Jason Bourne": 2 wds. |
| 40% | MISTERROGERS | 12 | TV host played by Tom Hanks in "A Beautiful Day in the Neighborhood" (2 wds.) |
| 40% | BENBRADLEE | 10 | Real-life newspaper editor played by Tom Hanks in "The Post": 2 wds. |
| 39% | SLEEPERAGENTS | 13 | What the lead characters in "The Americans" actually are: 2 wds. |
| 39% | WHITEYWINN | 10 | Character played by actor Thomas Brodie-Sangster in the hit Netflix television drama mini-series "Godless": 2 wds. |
| 39% | CHRISTIANKANE | 13 | The actor who plays the lead character and genius Jacob Stone on "The Librarians": 2 wds. |
| 39% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 39% | ERLICHBACHMAN | 13 | Lead character from "Silicon Valley", played by T.J. Miller, who has an innovation incubator, where "Pied Piper" is set up: 2 wds. |
| 39% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 39% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 39% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |
| 39% | RICKSANCHEZ | 11 | Genius but cynical scientist, one of the lead characters in "Rick and Morty" : 2 wds. |
| 38% | SONNYCORLEONE | 13 | Character played by James Edmund Caan in "The Godfather": 2 wds. |
| 38% | REBBROWN | 8 | Actor who played the titular character in the TV movie "Captain America" in 1979: 2 wds. |
| 38% | DOLORESHUERTA | 13 | Civil rights leader, played by Rosario Dawson in the 18-Across biopic, who received a Presidential Medal of Freedom in 2012: 2 wds. |
| 38% | DOCTORWATSON | 12 | Character played by 27-Across in the BBC's "Sherlock" (2 wds.) |
| 38% | GUSTAVOFRING | 12 | Character played by Giancarlo Esposito in "Breaking Bad", who owns Los Pollos Hermanos, besides being a prominent meth distributor: 2 wds. |
| 38% | LAURAINGALLS | 12 | Lead character on TV's "Little House on the Prairie," played by Melissa Gilbert: 2 wds. |
| 38% | DOCTORSTRANGE | 13 | Marvel superhero who was played by Benedict Cumberbatch in the titular 2016 film: 2 wds. |
| 38% | CHANNINGTATUM | 13 | "The Vow'' actor who voices one of the lead characters in "Smallfoot'': 2 wds. |