| 100% | CARE | 4 | The middle initial of ACA and ICU |
| 62% | CARE | 4 | The middle initial of A.C.A. and I.C.U. |
| 47% | FDR | 3 | Initials of the president between Hoover and Truman |
| 47% | JFK | 3 | Initials of the president between Eisenhower and Johnson |
| 47% | LBJ | 3 | Initials of the president between Kennedy and Nixon |
| 47% | FDR | 3 | Initials of the US president between Hoover and Truman |
| 45% | SSE | 3 | Compass direction in the middle of south and southeast |
| 44% | STAR | 4 | Symbol in the middle of the flags of Ghana and Senegal |
| 43% | SEUSS | 5 | Middle name of the “Green Eggs and Ham” author Theodor Geisel |
| 42% | CSLEWIS | 7 | Initialed author of "The Lion, the Witch and the Wardrobe": 3 wds. |
| 42% | ACT | 3 | The second "A" of "ACA" and "ADA" |
| 41% | SMACK | 5 | With 33-Down, precisely, as in the middle of 17-, 23-, 51- and 62-Across |
| 41% | AMADEUS | 7 | Mozart's middle name, and the title of a 1984 biopic |
| 41% | VET | 3 | November honoree who can be found in the middle of 17, 29, 46, and 62 Across |
| 41% | SHIRE | 5 | The region of Tolkien's Middle-earth in which Bilbo and Frodo Baggins live |
| 40% | TYPE | 4 | Synonym for "class" found in the middle of 21- and 54-Across and 3- and 35-Down |
| 40% | TANIA | 5 | Actress Raymonde of Lost and Malcolm in the Middle |
| 39% | SKALD | 5 | One of a number of travelling Scandinavian poets of the Viking and Middle Ages |
| 39% | OFFTOAGOODSTART | 15 | Having initial success … as suggested by the beginnings of 17-, 24-, 47- and 60-Across? |
| 39% | DEES | 4 | The middle of "middle" |
| 39% | ENS | 3 | The middle of dinner? |
| 38% | ELMER | 5 | Hunter with a middle initial of J |
| 38% | PER | 3 | The middle of 24 Across |
| 38% | TAC | 3 | The middle X of XXX |
| 38% | NUCLEUS | 7 | The middle of an atom |
| 38% | WED | 3 | The middle of next wk. |
| 38% | TEES | 4 | The middle letters of "letter" |
| 38% | DDE | 3 | Initials of the 34th president |
| 38% | PH/FONETICALLY | 14 | Middle of the quip ... and a hint to eight squares in this puzzle |
| 37% | CHOROID | 7 | The middle coat of the eyeball |