| 100% | CELL | 4 | The one thing about an amoeba |
| 49% | LIGHTBULB | 9 | The bright thing that goes on when one has an idea |
| 48% | BLOB | 4 | 1958 horror movie about an amoeba-like monster, with "The" |
| 47% | BLOB | 4 | 1958 or 1988 horror movie about an amoeba-like monster, with "The" |
| 45% | CELL | 4 | An amoeba has one |
| 44% | CELL | 4 | An amoeba has just one |
| 44% | CELL | 4 | An amoeba only has one |
| 44% | ONESOCK | 7 | The odd thing about laundry |
| 43% | SNAIL | 5 | The 2013 film Turbo is about an unusually fast one |
| 43% | CELL | 4 | An amoeba consists of just one |
| 42% | CELL | 4 | What an amoeba has one of |
| 41% | NEITHER | 7 | Not one thing nor the other |
| 41% | CONDUCTOR | 9 | The one who directs an orchestra |
| 41% | EQUATED | 7 | Considered one thing the same as another |
| 41% | BOSSBABY | 8 | Animated film about an infant businessman: The __ |
| 41% | DID | 3 | "___ you hear the one about ... " (joke start) |
| 40% | IVAN | 4 | The One and Only ___ (children's book about a gorilla) |
| 40% | HYPOCRISY | 9 | Saying one thing, but doing the exact opposite |
| 40% | AMANCALLEDHORSE | 15 | Film about an aristocrat captured by the Sioux |
| 40% | ARGON | 5 | About one percent of the atmosphere |
| 40% | OBOIST | 6 | One giving the orchestra an A |
| 40% | SIN | 3 | One of the seven "deadly" things |
| 40% | USURPERS | 8 | Ones taking things the wrong way |
| 39% | HUSBAND | 7 | Oscar Wilde wrote about An Ideal one in 1895 |
| 39% | HUSBAND | 7 | Oscar Wilde wrote a play about An Ideal one |
| 39% | ANNIE | 5 | Musical about an orphan that features the song "Tomorrow" |
| 39% | THETHING | 8 | John Carpenter film about an alien in the Arctic |
| 39% | LESS | 4 | "That's one ___ thing to worry about" |
| 39% | ISLE | 4 | One of about 700 in the Bahamas |
| 39% | SIDE | 4 | One of the eight on an Octagon |