| 100% | INNOCENT | 8 | The only papal name to have ever begun with I |
| 40% | VANADIUM | 8 | The only chemical element to begin with a V |
| 40% | XENON | 5 | The only chemical element with a name that begins with an x |
| 37% | TAYLORSWIFT | 11 | Only person in the arts ever to be named Time's Person of the Year |
| 36% | DOROTHY | 7 | Character who sings with the Scarecrow in "If I Only Had a Brain" |
| 36% | ITHURTSOBAD | 11 | Susan Tedeschi song with the lyric "You were the best man I ever had" |
| 36% | SOBAD | 5 | Eminem rap with the lyric "Guarantee I'll be the greatest thing you ever had" |
| 35% | HAMMERSTEIN | 11 | Oscar ___, the only man named Oscar to have won an Oscar so far |
| 35% | BYE | 3 | "___ ___ ___" (NSYNC song with the lyrics "I just want to tell you that I've had enough") |
| 34% | PITTSBURGH | 10 | City that had the final letter of its name removed in 1891, only to be restored in 1911 |
| 34% | SAHL | 4 | Satirist who said "If you were the only person left on the planet, I would have to attack you. That's my job" |
| 34% | TILLYOULOVEME | 13 | Reba McEntire song with the lyric "I guess I can wait if that's what I have to do" |
| 34% | MAGGIENELSON | 12 | Her 2009 book opens, “Suppose I were to begin by saying I had fallen in love with a color” |
| 34% | EGOCENTRIC | 10 | Like someone who only has I's for you? ... or an apt description of the answers to starred clues |
| 34% | SAHL | 4 | Political satirist who said "If you were the only person left on the planet, I would have to attack you. That's my job" |
| 33% | TIN | 3 | The only chemical element with a three-letter name |
| 33% | ERIE | 4 | The only Great Lake with a four-letter name |
| 33% | GOTYE | 5 | One-named singer with the hit "Somebody That I Used to Know" |
| 33% | IOWA | 4 | The only US state whose name starts with two vowels |
| 33% | PERU | 4 | The only South American country with a four-letter name |
| 33% | MAINE | 5 | The only U.S. state with a one-syllable name |
| 33% | ZEE | 3 | Arizona is the only state to have one |
| 33% | MENTAL | 6 | Having to do with the mind |
| 33% | RENAL | 5 | Having to do with the kidneys |
| 33% | GASTRIC | 7 | Having to do with the stomach |
| 32% | SHILO | 5 | Neil Diamond song with the lyrics, "When I was young / I used to call your name / When no one else would come" |
| 32% | SHILO | 5 | Neil Diamond song with the lyrics "When I was young / I used to call your name / When no one else would come" |
| 32% | FASTRELIEF | 10 | The only thing we have to fear is ... feeling better quickly? |
| 32% | NERDIER | 7 | Less likely to have lunch with the cool kids |
| 32% | IOWA | 4 | Only state name beginning with two vowels |