| 100% | ACEOLOGY | 8 | The science of remedies and therapeutics |
| 59% | PHYSICS | 7 | The science of matter and energy |
| 58% | MEDICINE | 8 | The science of good health and treating disease |
| 57% | PATHOLOGY | 9 | The science of the causes and effects of diseases |
| 57% | PATHOLOGY | 9 | The science of the causes and effects of disease |
| 56% | ASTRONOMY | 9 | Science of the stars and planets |
| 54% | GEOLOGY | 7 | Science of the physical earth, rocks, and sediment |
| 53% | HAPPINESS | 9 | What the science of well-being studies ... and the theme of this puzzle |
| 52% | OPTOMETRY | 9 | The medical science of eyes and vision |
| 50% | NEBULA | 6 | Annual award presented by the Science Fiction and Fantasy Writers of America |
| 49% | BILLNYE | 7 | "Undeniable: Evolution and the Science of Creation" author |
| 48% | HUGHES | 6 | John —, director of films The Breakfast Club and Weird Science |
| 48% | NYE | 3 | "Undeniable: Evolution and the Science of Creation" author Bill |
| 48% | NYE | 3 | "Undeniable: Evolution and the Science of Creation" author Bill ___ |
| 48% | BIOLOGY | 7 | The science of life |
| 48% | DENTISTRY | 9 | The science of teeth |
| 48% | GENETICS | 8 | The science of heredity |
| 48% | DIDACTICS | 9 | The science of teaching |
| 47% | MIXOLOGY | 8 | The science of creating cocktails |
| 47% | MEDICINE | 8 | The science of disease-treating |
| 47% | CARTOLOGY | 9 | The science of map making |
| 46% | TAXONOMY | 8 | The science of classifying living things |
| 46% | ECOLOGY | 7 | The science of relationships between organisms |
| 46% | OPTICS | 6 | The science of light; public perceptions |
| 46% | KURTVONNEGUT | 12 | American novelist in the Science Fiction and Fantasy Hall of Fame who was born in 1922 (2 wds.) |
| 45% | ACOUSTICS | 9 | The science of sound, used in music |
| 45% | PODIATRY | 8 | The science of treating foot health problems |
| 45% | DOOMEDPLANET | 12 | The —, tenth and final volume of science fiction novel series Mission Earth by L Ron Hubbard |
| 45% | DNA | 3 | "Native American ___: Tribal Belonging and the False Promise of Genetic Science" (Kim TallBear book) |
| 45% | BILLNYE | 7 | Who wrote "Undeniable: Evolution and the Science of Creation" |