| 100% | TIBERIUS | 8 | The T in James T Kirk, played by William Shatner |
| 64% | USSENTERPRISE | 13 | Fictional spaceship captained by William Shatner as James T. Kirk in early "Star Trek" films (2 wds.) |
| 60% | WILLIAMSHATNER | 14 | Actor who first played James T. Kirk, the captain played by Chris Pine in the new "Star Trek" films (2 wds.) |
| 58% | SHATNER | 7 | William —, actor who played James T Kirk in US television series Star Trek |
| 57% | SPOCK | 5 | Captain Kirk and ___, TV duo from the "Star Trek" franchise originally played by William Shatner and Leonard Nimoy |
| 55% | CHRISPINE | 9 | Actor who plays James T. Kirk in the "Star Trek" reboot films (2 wds.) |
| 53% | JAMESKIRK | 9 | The Star Trek character played by William Shatner |
| 49% | ETTA | 4 | James who was played by Beyoncé in the biopic "Cadillac Records" |
| 49% | KINGJOHN | 8 | The Life and Death of —, stage play by William Shakespeare first published in 1623 |
| 47% | JAMESTKIRK | 10 | "Star Trek" character played by William Shatner, who is the captain of the starship USS Enterprise: 3 wds. |
| 46% | MORIARTY | 8 | James ___, character played by Andrew Scott in the British crime drama "Sherlock" |
| 46% | ULTRON | 6 | Supervillain played by James Spader in the second Avengers movie |
| 46% | OLSEN | 5 | Photographer James played by Mehcad Brooks in The CW's "Supergirl" |
| 45% | DESDEMONA | 9 | Wife of Othello in the play of that name by William Shakespeare |
| 45% | FLINT | 5 | Captain James ___, fictional pirate played by Toby Stephens in the 2014 TV series "Black Sails" |
| 45% | REMO | 4 | ___ Williams, character played by Fred Ward in an action movie by the same name |
| 44% | LANDO | 5 | Calrissian played by Billy Dee Williams and Donald Glover in the "Star Wars" franchise |
| 44% | KEATING | 7 | John ___, iconic English teacher played by Robin Williams in the 1989 film "Dead Poets Society" |
| 43% | GUNTHER | 7 | The famous barista in Central Perk who speaks Dutch and English, played by James Michael Tyler in "Friends" |
| 43% | KIRK | 4 | "Star Trek" captain played by William Shatner |
| 42% | OMAR | 4 | Character played by Michael K. Williams in “The Wire” |
| 42% | KIRK | 4 | "Star Trek" captain played by William Shatner and Chris Pine |
| 42% | PATCH | 5 | ___ Adams, character based on a real-life doctor who was played by Robin Williams in the eponymous 1998 film |
| 42% | NBA | 3 | The league in which LeBron James plays: Abbr. |
| 41% | BORDERERS | 9 | "The ___," sole play written by William Wordsworth that was published in 1842 |
| 41% | SONNYCORLEONE | 13 | Character played by James Edmund Caan in "The Godfather": 2 wds. |
| 40% | STARFLEET | 9 | Academy attended by James T. Kirk |
| 40% | PHASER | 6 | Weapon wielded by James T. Kirk |
| 40% | BRADBELLICK | 11 | Character played by Wade Williams who is introduced as the captain of Fox River's correctional officers in "Prison Break": 2 wds. |
| 40% | IOWAN | 5 | Like Captain James T. Kirk, by birth |