| 100% | MYGIRL | 6 | The Temptations' first #1 single |
| 76% | MYGIRL | 6 | The Temptations' first #1 hit |
| 63% | CHICKENFRIED | 12 | First #1 single on the Billboard country charts for 43-Across (2 wds.) |
| 58% | ICEICEBABY | 10 | First single by a rapper to reach #1 on the Billboard Hot 100 |
| 58% | VENUSWILLIAMS | 13 | First Black woman ranked No. 1 singles player in the Open Era |
| 58% | STARTREKKIN | 11 | 1987 no 1 single by The Firm |
| 58% | START | 5 | 1980 no 1 single by The Jam |
| 57% | LOVEMEDO | 8 | The Beatles' first single, 1962 |
| 57% | GONOW | 5 | 1964 no 1 single by The Moody Blues |
| 56% | LOVEMEDO | 8 | First single released by the Beatles |
| 56% | WORLD | 5 | The first "W" of 1-Across |
| 56% | BED | 3 | The first "B" of 1-Down |
| 56% | CLOSER | 6 | 4-Down's first #1 single as a vocalist with the Chainsmokers |
| 56% | WITHOUTME | 9 | 4-Down's first #1 single as the lead singer: 2 wds. |
| 56% | EYELEVEL | 8 | 1973 no 1 single by The Simon Park Orchestra |
| 55% | ISRAELITES | 10 | 1969 no 1 single by Desmond Dekker and The Aces |
| 53% | DEEPEST | 7 | "The First Cut Is the ___" (Rod Stewart single) |
| 53% | CDIII | 5 | 1,500 years before the Wright brothers' first flight |
| 53% | COMO | 4 | Singer with the first gold record single |
| 53% | SOS | 3 | Rihanna's first #1 single |
| 52% | BACKHOME | 8 | 1970 UK no 1 single by the England World Cup Squad ‘70 |
| 52% | VENUSWILLIAMS | 13 | First African-American tennis player to be ranked #1 in women's singles during the Open Era: 2 wds. |
| 52% | EMI | 3 | Producer of the Beatles' first single |
| 52% | WATERMELONSUGAR | 15 | Harry Styles’s first No. 1 single on the Billboard Hot 100 (August, 2020) |
| 51% | ICEICEBABY | 10 | First hip-hop single to top the Billboard Hot 100 (1990) |
| 50% | IOWA | 4 | State that hosted the first presidential caucuses on February 1 |
| 50% | STUCKON | 7 | __ You; first number 1 hit of the 1960s for Elvis |
| 49% | THREETIMESALADY | 15 | First #1 hit for the Commodores |
| 49% | LORENA | 6 | Ochoa who was the first No. 1 ranked golfer from Mexico |
| 49% | PSY | 3 | Singer in the first YouTube video to surpass 1 billion views |