| 100% | LABANIMAL | 9 | The title character of “Flowers for Algernon,” e.g. |
| 64% | CONMEN | 6 | The title characters of 1988's "Dirty Rotten Scoundrels," e.g. |
| 59% | CAT | 3 | The title character of the short story “Tobermory,” for one |
| 56% | ANI | 3 | Nickname for the title character of “Anora” |
| 51% | HANDL | 5 | Irene —, comedy actress who played the title character in 1970s ITV sitcom For the Love of Ada |
| 50% | PUN | 3 | The title of this puzzle, e.g. |
| 50% | RANGEBEDFELLOWS | 15 | The main characters of "Brokeback Mountain," e.g.? |
| 50% | NOVELETTE | 9 | "Flowers for Algernon," e.g. |
| 48% | TROUPE | 6 | The main characters of the film “The Travelling Players,” e.g. |
| 48% | AMORAL | 6 | Like the title character of Camus’s “The Stranger” |
| 48% | IAN | 3 | Title character of the BBC drama ''Bondmaker'' |
| 48% | ZHIVAGO | 7 | Title character of the 1958 Nobel novel |
| 47% | ALEC | 4 | Baldwin who voices the title character of "The Boss Baby" |
| 47% | MARS | 4 | Whence the title character of “Stranger in a Strange Land” |
| 47% | ERIK | 4 | Title character of "The Phantom of the Opera" |
| 47% | SAURON | 6 | Title character of "The Lord of the Rings" |
| 47% | DIEGO | 5 | Title character of a "Dora the Explorer" spinoff |
| 46% | APE | 3 | The title character in "Mighty Joe Young," for one |
| 46% | EXAM | 4 | The "E" of G.R.E., for short |
| 46% | HARTMAN | 7 | Soap title character of the 1970's |
| 46% | BEATRIXPOTTER | 13 | Author/illustrator who created the title character of 18-Across: 2 wds. |
| 45% | DREAMER | 7 | Someone who fantasizes a lot, like the title character of 15-/47-Across |
| 45% | GARFIELD | 8 | Fictional lasagna-loving cat who is the title character of a comic strip |
| 45% | PYM | 3 | Title character of the only novel that Edgar Allan Poe wrote |
| 45% | PMS | 3 | The leaders of Thailand and Malaysia, e.g., for short |
| 44% | EMMA | 4 | Title character from the village of Highbury, 1815 |
| 44% | TESTPREP | 8 | Course of study for the SAT, e.g. |
| 44% | XXXXX | 5 | Helper of the title character of Netflix's "Wednesday" |
| 44% | NANETTE | 7 | Title character singing in the "Tea for Two" duet |